Interleukin-6 and interleukin-10 levels in chronic lymphocytic leukemia: correlation with phenotypic characteristics and outcome
Interleukin-6 and interleukin-10 levels in chronic lymphocytic leukemia: correlation with phenotypic characteristics and outcome
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DOI：
10.1182/blood.v97.1.256
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发表时间：
2001-01-01
期刊：
影响因子：
20.3
通讯作者：
Kurzrock, R
中科院分区：
文献类型：
--
作者：
Fayad, L;Keating, MJ;Kurzrock, R
为探讨慢性淋巴细胞白血病（CLL）患者血清白细胞介素-g（IL-6）和IL-10水平与预后的关系，采用酶联免疫吸附法分别检测了159例和151例CLL患者血清IL-6和IL-10水平，并与健康对照组（IL-6组55例，IL-10组37例）进行比较。细胞因子水平与临床特征和生存率相关。CLL患者血清IL-6水平高于正常对照组，（中位数，1.45 pg/mL;范围，无法检测到110 pg/mL）（中位数，不可检测;范围，不可检测至4.30 pg/mL）CLL患者血清IL-10水平明显高于正常对照组（P <0.0001），（中位数，5.04 pg/mL;范围，无法检测到74 pg/mL）（中位数，不可检测;范围，不可检测至13.68 pg/mL）（P < .00001），测量EB病毒衍生的和人IL-10的测定产生比主要测量人IL-10的测定更高的值。
The objective of this study was to examine the correlation between serum interleukin-g (IL-6) and IL-10 levels and outcome in chronic lymphocytic leukemia (CLL), Serum IL-6 and IL-10 levels were measured by enzyme-linked immunoabsorbent assays from 159 and 151 CLL patients, respectively, and from healthy control subjects (n = 55 [IL-6]; n = 37 [IL-10]). Cytokine levels were correlated with clinical features and survival. Serum IL-6 levels were higher in CLL patients (median, 1.45 pg/mL; range, undetectable to 110 pg/mL) than in control subjects (median, undetectable; range, undetectable to 4.30 pg/mL) (P < .0001), Serum IL-10 levels were higher in CLL patients (median, 5.04 pg/mL; range, undetectable to 74 pg/mL) than in normal volunteers (median, undetectable; range, undetectable to 13.68 pg/mL) (P < .00001), Assays measuring both Epstein-Barr virus-derived and human IL-10 yielded higher values than assays measuring primarily human IL