Increased production of immature myeloid cells in cancer patients: A mechanism of immunosuppression in cancer
Increased production of immature myeloid cells in cancer patients: A mechanism of immunosuppression in cancer
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DOI：
10.4049/jimmunol.166.1.678
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发表时间：
2001-01-01
影响因子：
4.4
通讯作者：
Gabrilovich, DI
中科院分区：
文献类型：
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作者：
Almand, B;Clark, JI;Gabrilovich, DI
这些细胞的异常分化导致树突状细胞（DC）功能缺陷，是肿瘤逃避免疫系统控制的一个重要机制。此前我们已经证明，癌症患者体内树突状细胞的数量和功能显著降低。这种效应与外周血中未成熟细胞（ImC）的积聚密切相关。在这项研究中，我们对这些未成熟细胞的性质和功能作用进行了研究。通过流式细胞术、电子显微镜、集落形成试验以及在不同细胞生长因子存在下的细胞分化，我们确定未成熟细胞群由一小部分（……此处句子不完整）组成。
Defective dendritic cell (DC) function caused by abnormal differentiation of these cells is an important mechanism of tumor escape from immune system control. Previously, we have demonstrated that the number and function of DC were dramatically reduced in cancer patients. This effect was closely associated with accumulation of immature cells (ImC) in peripheral blood. In this study, we investigated the nature and functional role of those ImC, Using dow cytometry, electron microscopy, colony formation assays, and cell differentiation in the presence of different cell growth factors, we have determined that the population of ImC is composed of a small percentage (