Clinicopathologic Significance of KIAA1199 Overexpression in Human Gastric Cancer
Clinicopathologic Significance of KIAA1199 Overexpression in Human Gastric Cancer
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DOI：
10.1245/s10434-009-0469-6
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发表时间：
2009-07-01
影响因子：
3.7
通讯作者：
Mori, Masaki
中科院分区：
文献类型：
--
作者：
Matsuzaki, Shinji;Tanaka, Fumiaki;Mori, Masaki
KIAA 1199是一个内耳特异性基因，编码KIAA 1199蛋白，其功能尚不清楚。KIAA 1199可能是一个新的Wnt信号正调控靶点。本研究采用半定量逆转录聚合酶链反应（RT-PCR）检测KIAA 1199在胃癌手术标本中的表达，并结合临床和病理因素分析其表达状况。进行单变量和多变量分析。结果：KIAA 1199 mRNA在癌组织中的表达明显高于癌旁正常组织（P <0. 01）。根据KIAA 1199在肿瘤中的表达情况将病例分为高表达组（n = 39）和低表达组（n = 71）。KIAA 1199低表达组5年生存率（61.2%）明显高于高表达组（29.6%）（P < 0.05）。高表达组中肿瘤分化程度、淋巴结转移、远处转移和腹膜转移阳性率高于低表达组（P分别为0.02、0.08、0.01和0.03）。KIAA 1199的表达是影响胃癌患者预后的独立因素（P = 0.03），多因素分析显示KIAA 1199在胃癌组织中的高表达与胃癌患者的预后和淋巴结转移有关。KIAA 1199可能是一个在胃癌发生发展中起重要作用的新基因。
KIAA1199 is an inner-ear-specific gene which encodes KIAA1199 protein, the function of which is unknown. KIAA1199 might be a novel, positively regulated target of Wnt signaling. The aim of this study was to examine the expression of KIAA1199 in surgical specimens of gastric cancer to evaluate the clinical outcome.The expression of KIAA1199 mRNA was studied by semiquantitative reverse-transcription polymerase chain reaction (RT-PCR), and the expression status was analyzed from the viewpoint of clinical and pathological factors. Univariate and multivariate analyses were performed. In addition, an immunohistochemical study was performed in the selected samples.A significantly higher expression of KIAA1199 messenger RNA (mRNA) was recognized in tumor tissue compared with that of paired normal tissues (P < 0.01). The cases were divided into high- (n = 39) and low-expression (n = 71) groups according to KIAA1199 expression status in the tumor. The overall 5-year survival rate was significantly better in the KIAA1199 low-expression group (61.2%) than in the high-expression group (29.6%) (P < 0.05). Clinicopathological factors such as well and moderately tumor differentiation, positive lymph node metastasis, positive distant metastases, and positive peritoneal dissemination were more frequently observed in the high-expression group than in the low-expression group (P = 0.02, 0.08, 0.01, and 0.03, respectively). KIAA1199 expression was an independent prognostic factor (P = 0.03).KIAA1199 was highly expressed in gastric cancer, and was associated with prognosis and lymph node metastasis in multivariate analyses. Taken together, KIAA1199 may be a novel gene that plays an important role in progression of gastric cancer.