Simultaneous glutamate and perfusion fMRI responses to regional brain stimulation.
Simultaneous glutamate and perfusion fMRI responses to regional brain stimulation.
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同时谷氨酸和灌注功能磁共振成像对区域脑刺激的反应。
DOI：
10.1097/00004647-199810000-00002
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Koretsky,AP
中科院分区：
文献类型：
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作者：
Forman,SD;Silva,AC;Dedousis,N;Barbier,EL;Fernstrom,JD;Koretsky,AP
功能性磁共振成像（fMRI）的基础假设是局部脑活动与局部脑血流量（rCBF）密切相关，为了验证这种耦合程度，通过反向微透析注入γ-氨基丁酸-A拮抗剂印防己毒素（picrotoxinin）局部刺激大鼠皮层脑活动。在输注前和输注前30分钟内，脑活动的同步fMRI（rCBF）和神经化学（间质谷氨酸浓度）测量高度相关（r = 0.83）。印楝素诱导的刺激30分钟后，谷氨酸水平下降，但rCBF仍然升高，这表明在这些后期阶段，其他因素调节神经元神经递质和血流动力学之间的关系。
Functional magnetic resonance imaging (fMRI) rests on the assumption that regional brain activity is closely coupled to regional cerebral blood flow (rCBF)in vivo.To test the degree of coupling, cortical brain activity was locally stimulated in rats by reversed microdialysis infusion of picrotoxinin, a γ-aminobutyric acid-A antagonist. Before and during the first 30 minutes of infusion, simultaneous fMRI (rCBF) and neurochemical (interstitial glutamate concentration) measures of brain activity were highly correlated (r = 0.83). After 30 minutes of picrotoxinin-induced stimulation, glutamate levels decreased but rCBF remained elevated, suggesting that additional factors modulate the relationship between neuronal neurotransmitters and hemodynamics at these later stages.