Quantitative assessment of air trapping in chronic obstructive pulmonary disease using inspiratory and expiratory volumetric MDCT
Quantitative assessment of air trapping in chronic obstructive pulmonary disease using inspiratory and expiratory volumetric MDCT
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DOI：
10.2214/ajr.07.2820
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发表时间：
2008-03-01
影响因子：
5
通讯作者：
Nakajima, Yasuo
中科院分区：
文献类型：
--
作者：
Matsuoka, Shin;Kurihara, Yasuyuki;Nakajima, Yasuo
OBJECTIVE.本研究的目的是确定使用成对吸气和呼气容积MDCT扫描检测和量化空气潴留的衰减阈值，并评估密度参数是否可用于量化慢性阻塞性肺疾病（COPD）的气道功能障碍，无论肺气肿的程度如何。本研究纳入了36例接受64-MDCT的COPD患者。衰减在-500至-1，024 H之间的整个肺体积被分割为整个肺。衰减在-500和-950 H之间的肺体积被分割为受限肺，而小于-950 H的肺体积被分割为肺气肿并被消除。在吸气和呼气CT上获得衰减值低于阈值（）（范围为-850至-950 H）的有限肺的相对体积（相对体积，-950）和全肺的相对体积（相对体积，）。计算全肺和局限肺呼气后相对容积变化（n = 950）的差值。根据平均相对体积小于-950 H将患者分为两组。评价肺密度测定参数与反映气道功能障碍的肺功能试验（PFT）之间的相关性。在-860 H的上限阈值处观察到与PFT的最高相关性。在中度至重度肺气肿组（相对体积（15%），相对体积变化（860-950）与PFT结果显著相关，而相对体积变化（
OBJECTIVE. The purpose of our study was to determine the attenuation threshold value for the detection and quantification of air trapping using paired inspiratory and expiratory volumetric MDCT scans and to assess whether the densitometric parameter can be used for the quantification of airway dysfunction in chronic obstructive pulmonary disease (COPD) regardless of the degree of emphysema.MATERIALS AND METHODS. This study included 36 patients with COPD who underwent 64-MDCT. The entire lung volume with attenuation between -500 and -1,024 H was segmented as whole lung. The lung volume with attenuation between -500 and -950 H was segmented as limited lung, while the lung volume of less than -950 H was segmented as emphysema and eliminated. The relative volumes for limited lung (relative volume,,-950) with attenuation values below thresholds () ranging from -850 to -950 H, and relative volume for whole lung (relative volume,,,) were obtained on inspiratory and expiratory CT. Then the differences of relative volumes after expiration in whole lung (relative volume change,,,) and limited lung (relative volume change(n-950)) were calculated. Patients were classified into two groups according to mean relative volume less than -950 H. Correlations between densitometry parameters and pulmonary function tests (PFTs) reflecting airway dysfunction were evaluated.RESULTS. The highest correlation with PFTs was observed at the upper threshold of -860 H. In the moderate to severe emphysema group (relative volume( 15%), relative volume change(860-950) significantly correlated with the results of PFTs, whereas no significant correlations were seen between relative volume change(