OBJECTIVE PHYSICAL ACTIVITY, SEDENTARY TIME, AND INCIDENT DISABILITY IN OLDER ADULTS
OBJECTIVE PHYSICAL ACTIVITY, SEDENTARY TIME, AND INCIDENT DISABILITY IN OLDER ADULTS
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老年人的客观身体活动、久坐时间和意外残疾
DOI：
10.1093/geroni/igx004.901
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发表时间：
2017
影响因子：
7
通讯作者：
S. Kuamagai
中科院分区：
文献类型：
--
作者：
Tao Chen;Yuka Haeuchi;Takanori Honda;S. Chen;K. Narazaki;S. Nagayoshi;S. Kuamagai
大量证据表明，较高水平的中等到剧烈的体力活动(MVPA)与较低的残疾风险相关，而且一项新兴的文献表明，较高水平的久坐时间(ST)与较高的残疾风险相关。然而，大多数研究都是通过问卷调查来评估MVPA和ST。这项前瞻性研究调查了加速计评估的PA和ST与残疾风险的关系，来自基于预期人群的Sasaguri Genkimon研究的1,603名参与者，他们在2011年的基线年龄为≥65岁，没有残疾。2011年用三轴加速度计对MVPA和ST进行了评估。在随访期间，残疾发生率被定义为日本国家长期护理保险制度对个人支持或护理的首次认证。COX比例风险模型用于估计残疾发生的调整危险比(HR)和95%可信区间(CI)。在中位数3.8年的随访中，149名参与者(9.2%)被确定为意外残疾。在调整了性别、年龄、教育程度、生活状态、认知障碍、多发病、吸烟和饮酒状况后，MVPA水平越高，残疾风险越低。在对ST进行额外调整后，与最低三分位组相比，MVPA中较高三分位数组的残疾风险较低，调整后的HR(95%CI)分别为0.51(0.32~0.81)和0.52(0.30~0.91)。未观察到ST的相关性。这些数据表明，MVPA在预防残疾方面有明显的好处。
Substantial evidence shows that higher levels of moderate-to-vigorous physical activity (MVPA) are associated with lower risk of disability, and an emerging body of literature suggests a higher level of sedentary time (ST) is related to a higher risk of disability. However, most studies assessed MVPA and ST using questionnaires. This prospective study investigated the associations of accelerometer-assessed PA and ST with risk of disability among 1,603 participants from the prospective population-based Sasaguri Genkimon Study, who were aged ≥65 years and without disability at baseline in 2011. MVPA and ST were assessed by a tri-axial accelerometer in 2011. During follow-up, incidence of disability was defined as first certification for personal support or care by the national long-term care insurance system of Japan. Cox proportional hazards models were used to estimate adjusted hazard ratios (HR) and 95% confidence intervals (CI) for the onset of disability. Over a median follow-up of 3.8 years, incident disability was identified in 149 participants (9.2%). After adjusting for sex, age, education, living status, cognitive impairment, multi-morbidity, smoking and drinking status, higher level of MVPA was associated with lower risk of disability. After additional adjustment for ST, those in the two higher tertiles of MVPA showed lower risk of disability compared to the lowest tertile group, with adjusted HR (95% CI) of 0.51 (0.32–0.81) and 0.52 (0.30–0.91), respectively. No association was observed for ST. These data demonstrated clear benefits of MVPA for prevention of disability.