The impact of impaired mitochondrial function on retrograde signalling: a meta-analysis of transcriptomic responses.
The impact of impaired mitochondrial function on retrograde signalling: a meta-analysis of transcriptomic responses.
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DOI：
10.1093/jxb/err374
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发表时间：
2012-02
影响因子：
6.9
通讯作者：
M. Schwarzländer;Ann-Christine König;L. Sweetlove;I. Finkemeier
中科院分区：
文献类型：
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作者：
M. Schwarzländer;Ann-Christine König;L. Sweetlove;I. Finkemeier
线粒体在细胞代谢中占有中心地位。因此，它们的蛋白质补充必须动态地调整以适应细胞的代谢需求。由于>95%的线粒体蛋白质由核DNA编码，因此线粒体蛋白质组的调节需要感测细胞器状态并将其传达回细胞核的信号。这被称为逆行信号。线粒体紧密整合到细胞过程的网络中，因此线粒体逆行信号的输出不仅反馈给线粒体，而且还调节整个细胞的功能。许多转录组学研究已经评估了植物中逆行信号的作用。然而，除了线粒体信号的特定转录组输出之外，特定线粒体功能障碍的单一研究也可以测量次级效应。为了更好地理解线粒体逆行信号的输出和作用，对来自不同植物线粒体功能障碍模型的11个转录组数据集进行了荟萃分析。比较稳定突变体和短期化学处理的微阵列数据，揭示了线粒体逆行控制下反应的独特特征和共性。特别是，观察到以下功能类别的转录本的共同调节：植物-病原体相互作用，蛋白质生物合成和光合作用的光反应。一种新的模式的interorganellar信号，在其中的peption的影响过程中的质体和细胞的其他部分的可能性进行了讨论。
Mitochondria occupy a central position in cellular metabolism. Their protein complement must therefore be dynamically adjusted to the metabolic demands of the cell. As >95% of mitochondrial proteins are encoded by nuclear DNA, regulation of the mitochondrial proteome requires signals that sense the status of the organelle and communicate it back to the nucleus. This is referred to as retrograde signalling. Mitochondria are tightly integrated into the network of cellular processes, and the output of mitochondrial retrograde signalling therefore not only feeds back to the mitochondrion, but also regulates functions across the cell. A number of transcriptomic studies have assessed the role of retrograde signalling in plants. However, single studies of a specific mitochondrial dysfunction may also measure secondary effects in addition to the specific transcriptomic output of mitochondrial signals. To gain an improved understanding of the output and role of mitochondrial retrograde signalling, a meta-analysis of 11 transcriptomic data sets from different models of plant mitochondrial dysfunction was performed. Comparing microarray data from stable mutants and short-term chemical treatments revealed unique features and commonalities in the responses that are under mitochondrial retrograde control. In particular, a common regulation of transcripts of the following functional categories was observed: plant-pathogen interactions, protein biosynthesis, and light reactions of photosynthesis. The possibility of a novel mode of interorganellar signalling, in which the mitochondrion influences processes in the plastid and other parts of the cell, is discussed.