Molecular mechanisms of diabetic retinopathy: potential therapeutic targets.
Molecular mechanisms of diabetic retinopathy: potential therapeutic targets.
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DOI：
10.4103/0974-9233.154386
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发表时间：
2015-04
影响因子：
0.6
通讯作者：
El-Remessy AB
中科院分区：
文献类型：
--
作者：
Coucha M;Elshaer SL;Eldahshan WS;Mysona BA;El-Remessy AB
糖尿病视网膜病变（DR）是美国工作年龄成人失明的主要原因。研究表明氧化应激与糖尿病并发症的发展之间存在关联。然而，一般抗氧化剂的临床试验未能证明对糖尿病患者有效。越来越多的实验研究表明，氧化应激和炎症在血管和神经视网膜中的损伤作用表明其在DR发病机制中的关键作用。本文将概述DR的当前管理以及目前潜在的实验治疗干预措施，关注将氧化应激与炎症联系起来的分子，为治疗或预防DR提供潜在的治疗靶点。糖尿病状态下的分子事件可能为对抗疾病提供新的有效治疗工具。
Diabetic retinopathy (DR) is the leading cause of blindness in working-age adults in United States. Research indicates an association between oxidative stress and the development of diabetes complications. However, clinical trials with general antioxidants have failed to prove effective in diabetic patients. Mounting evidence from experimental studies that continue to elucidate the damaging effects of oxidative stress and inflammation in both vascular and neural retina suggest its critical role in the pathogenesis of DR. This review will outline the current management of DR as well as present potential experimental therapeutic interventions, focusing on molecules that link oxidative stress to inflammation to provide potential therapeutic targets for treatment or prevention of DR. Understanding the biochemical changes and the molecular events under diabetic conditions could provide new effective therapeutic tools to combat the disease.