EVOLUTION OF THE SNF2 FAMILY OF PROTEINS - SUBFAMILIES WITH DISTINCT SEQUENCES AND FUNCTIONS
EVOLUTION OF THE SNF2 FAMILY OF PROTEINS - SUBFAMILIES WITH DISTINCT SEQUENCES AND FUNCTIONS
复制标题
DOI：
10.1093/nar/23.14.2715
复制
发表时间：
1995-07-25
影响因子：
14.9
通讯作者：
HANAWALT, PC
中科院分区：
文献类型：
--
作者：
EISEN, JA;SWEDER, KS;HANAWALT, PC
SNF2蛋白家族包括来自多种物种的代表，其在细胞过程如转录调节中发挥作用（例如MOT1、SNF2和BRM），在有丝分裂期间维持染色体稳定性（例如北极星）和DNA损伤处理的各个方面，包括核苷酸切除修复（例如RAD16和ERCC6），重组途径（例如，RAD54）和复制后子链缺口修复（例如，RAD 5），该家族还包括许多功能未知的蛋白质，为了更好地表征该蛋白家族，我们使用分子系统发育技术来推断家族成员之间的进化关系。我们将SNF2家族分为多个亚家族，每一个都代表了我们提出的功能和进化上不同的群体，然后我们使用亚家族结构来预测SNF2家族中一些未表征蛋白质的功能。我们讨论了SNF2家族的一般性质和进化的进化分析可能产生的影响。
The SNF2 family of proteins includes representatives from a variety of species with roles in cellular processes such as transcriptional regulation (e.g, MOT1, SNF2 and BRM), maintenance of chromosome stability during mitosis (e.g. lodestar) and various aspects of processing of DNA damage, including nucleotide excision repair (e.g. RAD16 and ERCC6), recombinational pathways (e,g, RAD54) and post-replication daughter strand gap repair (e.g, RAD5), This family also includes many proteins with no known function, To better characterize this family of proteins we have used molecular phylogenetic techniques to infer evolutionary relationships among the family members, We have divided the SNF2 family into multiple subfamilies, each of which represents what we propose to be a functionally and evolutionarily distinct group, We have then used the subfamily structure to predict the functions of some of the uncharacterized proteins in the SNF2 family. We discuss possible implications of this evolutionary analysis on the general properties and evolution of the SNF2 family.