CHANGES IN THE SITE-SPECIFIC AND HISTOLOGY-SPECIFIC INCIDENCE OF GASTRIC-CANCER DURING A 50-YEAR PERIOD
CHANGES IN THE SITE-SPECIFIC AND HISTOLOGY-SPECIFIC INCIDENCE OF GASTRIC-CANCER DURING A 50-YEAR PERIOD
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DOI：
10.1016/0016-5085(95)90740-8
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发表时间：
1995-12-01
期刊：
影响因子：
29.4
通讯作者：
MELTON, J
中科院分区：
文献类型：
--
作者：
LOCKE, GR;TALLEY, NJ;MELTON, J
背景与目的：与胃癌总体发病率显著下降形成对比的是，据报道位于胃贲门的病例发病率有所上升。本研究的目的是确定在50年期间胃腺癌部位特异性和组织学特异性发病率的变化。方法：利用罗切斯特流行病学项目医疗记录关联系统，确定1941年至1990年间明尼苏达州奥姆斯特德县居民中所有胃腺癌病例（n = 342）。对每位患者的完整（住院和门诊）医疗记录进行了审查，并根据病理、手术、内镜和放射学报告确定肿瘤位置。对所有可用的组织学标本（n = 246）进行了独立审查。结果：胃癌总体发病率从20世纪40年代的每10万人年48.8例下降到20世纪80年代的每10万人年11.6例，而贲门腺癌的发病率在50年期间没有显著变化。食管胃交界处腺癌的发病率从每10万人年0.0例上升到1.9例，但病例数量较少。结论：在该人群中，胃贲门腺癌的发病率没有增加。其他人群中所报道的贲门癌增加可能是由于食管胃交界处腺癌发病率上升所致。
Background & Aims: In contrast to the dramatic decrease in the overall incidence of gastric cancer, there has been a reported increase in the incidence of cases located in the gastric cardia. The aim of this study was to identify changes in site- and histology-specific incidence rates of gastric adenocarcinoma during a 50-year period. Methods: The Rochester Epidemiology Project medical records linkage system was used to identify all cases of gastric adenocarcinoma among residents of Olmsted County, Minnesota, between 1941 and 1990 (n = 342). Each patient's complete (inpatient and outpatient) medical records were reviewed and tumor location determined from pathological, surgical, endoscopic, and radiological reports. All available histological specimens (n = 246) were reviewed independently. Results: The overall incidence of gastric cancer decreased from 48.8 per 100,000 person-years in the 1940s to 11.6 per 100,000 in the 1980s, whereas the incidence of adenocarcinoma of the cardia did not change significantly during the 50-year period. The incidence of adenocarcinoma of the esophagogastric junction increased from 0.0 to 1.9 per 100,000 person-years, but the number of cases was small. Conclusions: The incidence of adenocarcinoma of the gastric cardia has not increased in this population. The reported increase in cardia cancer in other populations may be due to an increasing incidence of adenocarcinoma of the esophagogastric junction.