THE DISTRIBUTION OF CHOLINE ACETYLTRANSFERASE ACTIVITY IN VERTEBRATE RETINA 1
THE DISTRIBUTION OF CHOLINE ACETYLTRANSFERASE ACTIVITY IN VERTEBRATE RETINA 1
复制标题
脊椎动物视网膜中胆碱乙酰转移酶活性的分布1
DOI：
10.1111/j.1471-4159.1976.tb01505.x
复制
发表时间：
1976
影响因子：
4.7
通讯作者：
David B. McDougal
中科院分区：
文献类型：
--
作者：
C. D. Ross;David B. McDougal
摘要-胆碱乙酰转移酶（ChAc）活性测定视网膜层从10脊椎动物。在所有动物中，活性最高的是在内网状层，中间活动的内核和神经节细胞层，和非常低的活动在感光器和外网状层和视神经。酶活性在内核层内的分布模式定量地对应于该层内无长突细胞的分布。在内网状层中ChAc活性的最低值和最高值之间发现了几乎90倍的物种差异。在恒温动物中发现的酶活性的变化，在内核层和内丛状层的无长突细胞突触的数量有关。但是，酶活性的差异通常大于物种间无长突细胞突触数量的差异。这些数据表明，在视网膜中的胆碱能神经元被发现主要是在无长突细胞类型，并不是所有的无长突细胞将被发现是胆碱能的。
Abstract— Choline acetyltransferase (ChAc) activity was determined in retinal layers from 10 vertebrates. In all animals, the highest activity was in the inner plexiform layer, intermediate activity in the inner nuclear and ganglion cell layers, and very low activity in the photoreceptor and outer plexiform layers and optic nerve. The pattern of distribution of enzyme activity within the inner nuclear layer corresponds quantitatively to the distribution of amacrine cells within that layer. A species difference of almost 90‐fold was found between the lowest and highest values for ChAc activity in inner plexiform layer. The variation in enzyme activity found among homeotherms in inner nuclear and inner plexiform layers is related to the number of amacrine cell synapses in the inner plexiform layer. But the differences in enzyme activity are generally greater than those which have been found in numbers of amacrine cell synapses between species. The data suggest that cholinergic neurons in retina are to be found predominantly among the amacrine cell types and that not all amacrine cells will be found to be cholinergic.