Diffusion tensor imaging and axonal tracking in the human brainstem
Diffusion tensor imaging and axonal tracking in the human brainstem
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DOI：
10.1006/nimg.2001.0861
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发表时间：
2001-09-01
期刊：
影响因子：
5.7
通讯作者：
Mori, S
中科院分区：
文献类型：
--
作者：
Stieltjes, B;Kaufmann, WE;Mori, S
弥散张量 MRI 用于演示脑干轴突连接的体内解剖图。可以识别皮质脊髓束（CST）、内侧丘系以及小脑上脚、内侧脚和下脚。此外，大脑脚可以细分为多个组成束，即额桥束、CST 和颞/顶/枕桥束。为每根纤维建立了解剖标志和跟踪阈值，并且使用这些标准，通过组内和组间可靠性评估的自动跟踪的再现性被发现很高（kappa > 0.82）。重建的纤维与现有的解剖知识很好地对应，验证了跟踪。将各个束的位置信息与定量 MRI 图进行配准，以逐个束自动测量 MRI 参数。结果表明，每个区域在水弛豫和扩散各向异性方面都具有独特的空间特征。 (C) 2001 年学术出版社。
Diffusion tensor MRI was used to demonstrate in vivo anatomical mapping of brainstem axonal connections. It was possible to identify the corticospinal tract (CST), medial lemniscus, and the superior, medial, and inferior cerebellar peduncles. In addition, the cerebral peduncle could be subparcellated into component tracts, namely, the frontopontine tract, the CST, and the temporo-/parieto-/occipitopontine tract. Anatomical landmarks and tracking thresholds were established for each fiber and, using these standards, reproducibility of automated tracking as assessed by intra- and interrater reliability was found to be high (kappa > 0.82). Reconstructed fibers corresponded well to existing anatomical knowledge, validating the tracking. Information on the location of individual tracts was coregistered with quantitative MRI maps to automatically measure MRI parameters on a tract-by-tract basis. The results reveal that each tract has a unique spatial signature in terms of water relaxation and diffusion anisotropy. (C) 2001 Academic Press.