Cytotoxin-Associated Gene-A-Seropositivity and Interleukin-1 Polymorphisms Influence Adverse Cardiovascular Events.
Cytotoxin-Associated Gene-A-Seropositivity and Interleukin-1 Polymorphisms Influence Adverse Cardiovascular Events.
复制标题
细胞毒素相关基因 A 血清阳性和白细胞介素 1 多态性影响不良心血管事件。
DOI：
10.1016/j.ijcha.2020.100498
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发表时间：
2020
影响因子：
2.9
通讯作者：
and Tsujita K.
中科院分区：
文献类型：
--
作者：
Tabata N;SuetaD;Arima Y;Okamoto K;Shono T;Hanatani S;Takashio S;Oniki K;Saruwatari J;Sakamoto K;Kaikita K;Sinning JM;Werner K;Nickenig G;Sasaki Y;Fukui T;and Tsujita K.
虽然细胞毒素相关基因A（CagA）血清阳性的细菌毒力因子和白细胞介素（IL）-1多态性的宿主遗传因子已被认为影响幽门螺杆菌（HP）相关疾病，但HP感染与急性冠状动脉综合征（ACS）之间的潜在机制尚不清楚。ACS后的临床结局包括2年随访期内的复合心血管事件，HP阳性患者发生主要结局的概率显著高于HP阴性患者。在缺乏IL-1基因多态性的情况下，HP阳性和HP阴性患者的心血管事件发生率无显著差异，而在存在IL-1基因多态性的情况下，心血管事件发生率有显著差异。CagA阳性、CagA阴性/HP阳性、CagA阴性/HP阴性患者的心血管事件发生率差异有统计学意义。此外，通过免疫组化染色，主动脉CagA阳性细胞被证实在血管中CagA阳性patients，而他们不能在CagA阴性patients.ConclusionsThe细菌毒力因子CagA和宿主geneticIL-1多态性影响不良心血管事件的发生率，可能通过感染动脉粥样硬化lesions.Registration：大学医院医学信息网络（UMIN）-CTR（http：//www.umin.ac.jp/ctr/）。
AimsAlthough the bacterial virulent factor of cytotoxin-associated gene-A (CagA)-seropositivity and the host genetic factors ofinterleukin (IL)-1polymorphisms have been suggested to influenceHelicobacter pylori (HP)-related diseases, the underlying mechanisms of the association betweenHPinfection and acute coronary syndrome (ACS) remain unknown.Methods and resultsAmong 341 consecutive ACS patients, the clinical outcomes after ACS included composite cardiovascular events within the 2-year follow-up period.A significantly higher probability of primary outcomes was observed inHPpositive patients than inHPnegative patients. There were no significant differences in the rate of cardiovascular events betweenHPpositive andHPnegative patients in the absence of anIL-polymorphism, while there were significant differences in the presence of anIL-polymorphism. There were significant differences in the rate of cardiovascular events among CagA positive, CagA negative/HPpositive and CagA negative/HPnegative patients. Moreover, via immunohistochemical staining, aortic CagA positive cells were confirmed in the vasa vasorum in CagA positive patients, whereas they could not be identified in CagA negative patients.ConclusionsThe bacterial virulence factor CagA and host geneticIL-1polymorphisms influence the incidence of adverse cardiovascular events, possibly through infection of atherosclerotic lesions.Registration:University Hospital Medical Information Network (UMIN)-CTR (http://www.umin.ac.jp/ctr/).Identifier:UMIN000035696.