Targeted and effective photodynamic therapy for cancer using functionalized nanomaterials.
Targeted and effective photodynamic therapy for cancer using functionalized nanomaterials.
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DOI：
10.1016/j.apsb.2016.01.007
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发表时间：
2016-07
期刊：
影响因子：
--
通讯作者：
Shim MS
中科院分区：
文献类型：
--
作者：
Hong EJ;Choi DG;Shim MS
光动力疗法（PDT）是一种新兴的非侵入性治疗策略，涉及光敏剂（PS）药物和外部光来治疗疾病。尽管PS介导的PDT取得了巨大进展，但其临床应用仍然受到传统PS药物较差的水溶性和组织/细胞特异性的阻碍。因此，人们付出了巨大的努力来开发纳米材料，以解决传统 PS 药物介导的 PDT 癌症治疗的根本挑战。本综述重点介绍了纳米平台开发的最新进展，其中各种功能化有机和无机纳米材料与 PS 药物相结合，可显着提高 PDT 的疗效和肿瘤选择性。本综述重点介绍了纳米平台开发的最新进展，其中各种功能化有机和无机纳米材料与光敏剂药物相结合，可显着提高光动力疗法的疗效和肿瘤选择性。
Photodynamic therapy (PDT) is an emerging, non-invasive therapeutic strategy that involves photosensitizer (PS) drugs and external light for the treatment of diseases. Despite the great progress in PS-mediated PDT, their clinical applications are still hampered by poor water solubility and tissue/cell specificity of conventional PS drugs. Therefore, great efforts have been made towards the development of nanomaterials that can tackle fundamental challenges in conventional PS drug–mediated PDT for cancer treatment. This review highlights recent advances in the development of nano-platforms, in which various functionalized organic and inorganic nanomaterials are integrated with PS drugs, for significantly enhanced efficacy and tumor-selectivity of PDT. This review highlights recent advances in the development of nano-platforms, in which various functionalized organic and inorganic nanomaterials are integrated with photosensitizer drugs, for significantly enhanced efficacy and tumor-selectivity of photodynamic therapy.