MAST-CELLS IN COLORECTAL NEOPLASIAS AND PREMALIGNANT DISORDERS
MAST-CELLS IN COLORECTAL NEOPLASIAS AND PREMALIGNANT DISORDERS
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DOI：
10.1007/bf02055605
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发表时间：
1995-03-01
影响因子：
3.9
通讯作者：
MUNICHOR, M
中科院分区：
文献类型：
--
作者：
LACHTER, J;STEIN, M;MUNICHOR, M
肥大细胞与直肠癌患者的预后密切相关。这项工作的目的是描述肥大细胞在结肠癌前病变中的作用。方法：在各种结肠疾病中，特别是那些具有癌前病变潜能的结肠疾病中，对原始细胞进行定量。肥大细胞作用的可能途径进行了研究，使用这些组织样本，通过测量基底膜和胶原层增厚。研究结果：癌切片中肥大细胞的平均数量为0.967/0.9 mm（2），各种结直肠肿瘤和相关疾病中肥大细胞的平均数量为1.36-3/0.9 mm（2），正常组织学标本中肥大细胞的平均数量为1.36-3/0.9 mm（2）。肥大细胞的数量在结肠的固有层水平是最多的，由于从内窥镜活检获得的样品的深度有限，该部位通常不被检查。结论：肥大细胞数量与癌前病变向结肠癌的发展相关。肥大细胞可作为结直肠肿瘤的标志物。
PURPOSE: Mast cells have recently been found to be well correlated with the prognosis of patients with rectal cancer. This work aimed to characterize the role of mast cells in colonic premalignant conditions. METHODS: blast cells were quantified in various colonic disorders, particularly those with premalignant potential. Possible avenues of mast cell action were investigated using these tissue samples, by measuring basement membrane and collagen layer thickening. RESULTS: The mean number of mast cells in carcinoma sections was 0.967/0.9 mm(2), in various colorectal neoplasias and related conditions: it ranged from 1.36-3/0.9 mm(2), and in normal histologic specimens it was These data established statistically significant differences in mast cell numbers in the colonic disorders studied. The number of mast cells is greatest in the lamina propria level of the colon, a site often not examined because of the limited depth of samples obtained from endoscopic biopsies. CONCLUSIONS: Mast cell numbers were found to be correlated to the development from premalignancy to colonic malignancy. Mast cells may be useful as markers of colorectal neoplasia.