White-matter tract integrity in late-life depression: associations with severity and cognition.
White-matter tract integrity in late-life depression: associations with severity and cognition.
复制标题
晚期抑郁症中的白色物质完整性：与严重性和认知的关联。
DOI：
10.1017/s0033291713001980
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发表时间：
2014-05
影响因子：
6.9
通讯作者：
Kumar A
中科院分区：
文献类型：
--
作者：
Charlton RA;Lamar M;Zhang A;Yang S;Ajilore O;Kumar A
虽然在老年抑郁症（LLD）中已经注意到灰质和白色物质的显著变化，但尚未完全描述涉及白质束的病理生理学。在这项研究中，我们检查了LLD与健康对照（HC）的特定白质束的完整性。年龄≥ 60岁的参与者从社区招募。样本包括23名临床诊断为LLD和23名HC的个体。计算双侧扣带和钩束的白质完整性指标[各向异性分数（FA）、平均扩散率（MD）、轴向扩散率（AD）和径向扩散率（RD）]。抑郁症的严重程度采用流行病学研究中心抑郁量表（CESD）进行测量。使用标准化神经心理学评估创建学习和记忆以及执行功能的综合评分。LLD组双侧扣带回和右侧钩束的白质完整性低于HC组（p ≤ 0.05）。在整个样本中，抑郁严重程度与双侧扣带和右侧钩束的完整性相关（p ≤ 0.05）。在患者中，抑郁症的严重程度与左钩束的完整性相关（p = 0.03）;这一束也与执行功能相关（p = 0.02）。在HC中，束完整性与抑郁评分无关;然而，学习和记忆与双侧钩束和双侧扣带的完整性相关;执行功能与右侧钩束和左侧扣带相关（p ≤ 0.05）。LLD患者的白质束完整性低于HC患者，并且与所有参与者的抑郁严重程度相关。在两组中，道的完整性与认知相关，但在HC中更强。
Although significant changes in both gray and white matter have been noted in late-life depression (LLD), the pathophysiology of implicated white-matter tracts has not been fully described. In this study we examined the integrity of specific white-matter tracts in LLD versus healthy controls (HC). Participants aged ≥60 years were recruited from the community. The sample included 23 clinically diagnosed individuals with LLD and 23 HC. White-matter integrity metrics [fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD)] were calculated in the bilateral cingulum and uncinate fasciculus. Depression severity was measured using the Center for Epidemiological Studies Depression Scale (CESD). Composite scores for learning and memory and executive function were created using standardized neuropsychological assessments. White-matter integrity was lower in LLD versus HC in the bilateral cingulum and right uncinate fasciculus (p≤0.05). In the whole sample, depression severity correlated with integrity in the bilateral cingulum and right uncinate fasciculus (p ≤0.05). In patients, depression severity correlated with the integrity of the left uncinate fasciculus (p=0.03); this tract also correlated with executive function (p=0.02). Among HC, tract integrity did not correlate with depression scores; however, learning and memory correlated with integrity of the bilateral uncinate fasciculus and bilateral cingulum; executive function correlated with the right uncinate and left cingulum (p ≤0.05). White-matter tract integrity was lower in LLD than in HC and was associated with depression severity across all participants. Tract integrity was associated with cognition in both groups but more robustly among HC.