Language dominance and mapping based on neuromagnetic oscillatory changes: comparison with invasive procedures
Language dominance and mapping based on neuromagnetic oscillatory changes: comparison with invasive procedures
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DOI：
10.3171/2009.7.jns09239
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发表时间：
2010-03-01
影响因子：
4.1
通讯作者：
Yoshimine, Toshiki
中科院分区：
文献类型：
--
作者：
Hirata, Masayuki;Goto, Tetsu;Yoshimine, Toshiki
Object.事件相关的脑振荡变化反映了局部脑激活。在以前的研究中，作者提出了一种新的方法来确定语言优势：使用合成孔径磁测法（SAM）检查额叶振荡的变化，在沉默阅读。作者在本研究中的目的是建立一个正常的模板，这种方法，以确认他们以前的研究结果与更大的患者群体，并评估他们的方法与语言定位。对14名健康志愿者进行统计学分组分析，以建立正常对照。然后在123名连续患者的更大人群中评估语言优势和定位。研究参与者被要求默读100个视觉呈现的单词。使用SAM，通过比较每个单词呈现之前1秒和之后1秒之间的每个体素的电流密度，获得振荡变化的空间分布作为Student t统计量。使用统计非参数映射对健康志愿者进行分组分析。语言优势的患者被确定根据偏侧指数（LI）计算使用峰值t值的左，右额叶去激活。语言优势进行了前瞻性评估，并与Wada测试（63例）的结果进行了比较。语言定位结果与刺激映射（17例）进行定量比较。对健康志愿者的分组分析表明，左侧额叶区域的β-低γ带去极化，左侧顶颞区的α-β带去极化。在患者中，118人（95.9%）检测到额叶语言区。额下回或额中回的β或低γ去皮质化的偏侧化与语言优势相对应。语言优势的定量评估，其结果是一致的，在51（85.0%）的60例和田测验的介绍。估计的额叶语言区和刺激阳性部位之间的距离为6.0 +/- 7.1 mm（平均值+/- SD）。这项研究是第一次在大规模人群中使用脑磁图（MEG）来确定语言优势，并将结果与Wada测试进行比较。此外，使用MEG获得的语言定位结果进行了比较，通过侵入性映射。作者的方法基于神经磁振荡变化，是一种无创评估额叶语言区的新方法，这是一种使用MEG偶极子方法存在问题的方法。合成孔径磁测法是一种非侵入性的替代Wada测试语言优势，并有助于确定刺激部位侵入性映射。(DOI：10.3171/2009.7.JNS09239）
Object. Event-related cerebral oscillatory changes reflect regional brain activation. In a previous study, the authors proposed a new method to determine language dominance: examine frontal oscillatory changes during silent reading by using synthetic aperture magnetometry (SAM). The authors' aims in the present study were to establish a normal template for this method, to confirm the results of their previous study with a larger patient population, and to evaluate their method with respect to language localization.Methods. A statistical group analysis of 14 healthy volunteers was conducted to establish a normal control. Language dominance and localization were then evaluated in a larger population of 123 consecutive patients. Study participants were instructed to silently read 100 visually presented words. Using SAM, the spatial distribution of the oscillatory changes was obtained as the Student t statistic by comparing the current density for each voxel between 1 second before and 1 second after each word presentation. Group analyses of the healthy volunteers were performed using statistical nonparametric mapping. Language dominance in the patients was determined according to the laterality index (LI) calculated using peak t values of the left and right frontal desynchronizations. Language dominance was prospectively assessed, and the results were compared with those of the Wada test ( 63 patients). Language localization results were quantitatively compared with those of stimulation mapping ( 17 patients).Results. Group analysis of the healthy volunteers indicated beta to low gamma band desynchronization in the left frontal area and a to beta desynchronization in the left parietotemporal areas. In patients, the frontal language areas were detected in 118 persons (95.9%). Lateralization of beta or low gamma desynchronization in the inferior or middle frontal gyri corresponded well with language dominance. The introduction of the LI resulted in a quantitative evaluation of language dominance, whose results were concordant with those of the Wada test in 51 (85.0%) of 60 cases. The distance between the estimated frontal language areas and stimulation-positive sites was 6.0 +/- 7.1 mm ( mean +/- SD).Conclusions. This study is the first in which magnetoencephalography (MEG) was used to determine language dominance in a large population, and the results were compared with those of the Wada test. Moreover, language localization results obtained using MEG were compared with those obtained by invasive mapping. The authors' method, which is based on neuromagnetic oscillatory changes, is a new approach for noninvasively evaluating the frontal language areas, a procedure that has been problematic using MEG dipole methods. Synthetic aperture magnetometry is a noninvasive alternative to Wada testing for language dominance and helps to determine stimulation sites for invasive mapping. (DOI: 10.3171/2009.7.JNS09239)