Variability of plasma catecholamine levels: age, duration of posture and time of day.
Variability of plasma catecholamine levels: age, duration of posture and time of day.
复制标题
血浆儿茶酚胺水平的变异性：年龄、姿势持续时间和一天中的时间。
DOI：
10.1111/j.1365-2125.1979.tb04718.x
复制
发表时间：
1979
影响因子：
3.4
通讯作者：
R. Gordon
中科院分区：
文献类型：
--
作者：
N. Saar;R. Gordon
1.为了确定影响血浆儿茶酚胺水平的因素，以及为了重现性和可比性而可能控制的因素，用双同位素技术重复测定了正常人血浆去甲肾上腺素+肾上腺素（NA + A）。2.年龄和姿势是血浆NA + A水平的重要决定因素，而一天中的时间不太重要。3.水平较高的老年男子年龄在70- 92岁比年轻男子年龄在19- 28岁，测量后30分钟或9小时（过夜）横卧，或5分钟后站立。4.卧位和直立姿势的持续时间都很重要。9小时后（过夜）的卧位水平低于30分钟后（上午）。直立姿势引起的水平增加2分钟内。水平达到峰值之间的5和20分钟，12小时后低于20分钟后，但直立水平始终高于水平后9小时横卧。5.在连续卧位期间，水平在24.00小时最低，此后升高。在第二次住院期间，09.00 h的水平再次高于过夜卧床后06.00 h的水平。6.通过重复采样获得的水平的变异性较低，而坐着，在一个正常的直立的一天，比30分钟后横卧。直立腿可能是心血管交感神经活动的更好指标。
1. In order to define factors which influence plasma catecholamine levels, and which might be controlled in the interests of reproducability and comparability, plasma noradrenaline plus adrenaline (NA + A) was measured repeatedly in normal subjects by a double isotope technique. 2. Age and posture were important determinants for plasma NA + A levels, whereas time of day was less important. 3. Levels were higher in old men aged 70--92 years than in young men aged 19--28 years, measured after 30 min or 9 h (overnight) recumbency, or after 5 min standing. 4. Duration of recumbency and of upright posture were both important. Recumbent levels were lower after 9 h (overnight) than after 30 min (mid-morning). Upright posture caused an increase in levels within 2 min. Levels peaked between 5 and 20 min, were lower after 12 h than after 20 min, but upright levels were always higher than levels after 9 h recumbency. 5. During continuous recumbency, levels were lowest at 24.00 h, and increased thereafter. During a second hospitalisation, levels at 09.00 h were again higher than levels at 06.00 h after overnight recumbency. 6. Variability of levels obtained by repeated sampling was lower while sitting, during a normal upright day, than after 30 min recumbency. Upright legels may be a better index of cardiovascular sympathetic activity.