Structural insights into bacterial modulation of the host cytoskeleton.

Structural insights into bacterial modulation of the host cytoskeleton.
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对宿主细胞骨架的细菌调节的结构见解。

DOI:
10.1016/j.sbi.2004.09.011
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发表时间:
2004
影响因子:
6.8
通讯作者:
Stebbins,CErec
Stebbins,CErec
中科院分区:
生物学2区
文献类型:
--
作者:
Stebbins,CErec

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许多细菌病原体在感染过程中操纵宿主细胞的细胞骨架。这种细胞骨架调节可以发生在病原体和宿主之间的几个接触点,并涉及细胞外受体,细胞内信号转导和细胞骨架蛋白本身。在过去的十年中,细菌致病机理领域取得了巨大的进展,因此结构知识对于充分了解病原体-宿主界面的生物学是及时和必要的。最近的几个例子涉及细菌蛋白的目标肌动蛋白,Rho家族GTPases和细胞外受体的病原体的真核细胞骨架调制的结构理解作出了贡献。
Many bacterial pathogens manipulate the host cell cytoskeleton during infection. Such cytoskeletal modulation can occur at several points of contact between the pathogen and the host, and involves extracellular receptors, intracellular signal transduction and cytoskeletal proteins themselves. The field of bacterial pathogenesis has progressed dramatically over the past decade, such that structural knowledge is both timely and essential for a full appreciation of the biology at the pathogen–host interface. Several recent examples involving bacterial proteins that target actin, Rho family GTPases and extracellular receptors have contributed to a structural understanding of eukaryotic cytoskeletal modulation by pathogens.
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