INFECTION BY HERPES-SIMPLEX VIRUS AND CELLS OF NERVOUS-SYSTEM ORIGIN - CHARACTERIZATION OF A NON-PERMISSIVE INTERACTION
INFECTION BY HERPES-SIMPLEX VIRUS AND CELLS OF NERVOUS-SYSTEM ORIGIN - CHARACTERIZATION OF A NON-PERMISSIVE INTERACTION
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DOI：
10.1099/0022-1317-39-1-9
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发表时间：
1978-01-01
影响因子：
3.8
通讯作者：
LEVINE, M
中科院分区：
文献类型：
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作者：
ADLER, R;GLORIOSO, JC;LEVINE, M
对单纯疱疹病毒1型(HSV-1)在大鼠神经系统来源的不同细胞系中的复制进行了研究。用HSV-1株Kos感染新生大鼠神经胶质原代细胞，可产生正常的子代病毒。神经胶质瘤细胞株B9和B15对HSV-1(Kos)复制有部分限制(减少10-100倍)，而神经细胞株B103对HSV-1(Kos)复制不允许(减少1000倍)。在感染B103细胞中未检测到病毒DNA的合成。至少诱导了一些病毒大分子合成，包括胸苷激酶、DNA聚合酶和病毒结构蛋白的产生。
Replication of herpes simplex virus type 1 (HSV-1) was studied in various cell lines of rat nervous system origin. Infection of neonatal rat glial primary cells with HSV-1, strain KOS, produced normal yields of progeny virus. Glioma lines B9 and B15 were permissive, the neuronal line B50 was partially restricted (10- to 100-fold reduction) and the neuronal line B103 was non-permissive (> 1000-fold reduction) for HSV-1 (KOS) replication. Synthesis of virus DNA in infected B103 cells was not detected. At least some virus macromolecular synthesis was induced, including production of thymidine kinase, DNA polymerase and virus structural proteins.