CELL LINEAGE RESTRICTIONS IN THE CHICK-EMBRYO HINDBRAIN
CELL LINEAGE RESTRICTIONS IN THE CHICK-EMBRYO HINDBRAIN
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DOI：
10.1098/rstb.1991.0017
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发表时间：
1991-03-29
影响因子：
6.3
通讯作者：
LUMSDEN, A
中科院分区：
文献类型：
--
作者：
LUMSDEN, A
在鸡胚胎发育过程中，后脑的早期神经元分化和轴突发生遵循与该区域的分段形态相一致的分段模式。细胞标记实验表明，这些片段，或称菱形核，是血统限制单位，每个都构成后脑的一个特定部分。这提出了一种有趣的可能性，即就像在发育中的苍蝇一样，同色异谱作用被用来以极高和可靠的精度生成特定水平的解剖结构。在后脑中，与许多无脊椎动物一样，谱系祖先可能在决定细胞命运方面起着重要作用。因此，在这个身体区域看到的片段可能反映了曾经在脊椎动物和无脊椎动物共同存在的祖先中存在的类似情况。
During development of the chick embryo, early neuronal differentiation and axonogenesis in the hindbrain follow a segmented pattern in register with the segmented morphology of this region. Cell marking experiments have shown that the segments, or rhombomeres, are lineage-restriction units each constructing a defined piece of the hindbrain. This raises the interesting possibility that, as in the developing fly, metamerism is used to generate level-specific anatomical structures with great and reliable precision. In the hindbrain, as for many invertebrates, lineage ancestry may be important in the determination of cell fate. The segmentation seen in this body region could therefore reflect a similar condition once present in the ancestor common to vertebrates and invertebrates.