Genomic organization of the mouse T-cell receptor beta-chain gene family.
Genomic organization of the mouse T-cell receptor beta-chain gene family.
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小鼠 T 细胞受体 β 链基因家族的基因组结构。
DOI：
10.1073/pnas.84.11.3846
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发表时间：
1987
影响因子：
11.1
通讯作者：
Hood,L
中科院分区：
文献类型：
--
作者：
Lai,E;Barth,RK;Hood,L
我们结合了三种不同的方法，t细胞系的缺失定位，场反转凝胶电泳和cosmid克隆的限制性定位，构建了小鼠t细胞受体β链基因家族的物理图谱。我们绘制了19个可变（V β）基因片段和两个多样性（D β）和连接（J β）基因片段和恒定（C β）基因簇。这些β链基因家族成员的DNA跨度大约等于450千碱基，不包括DNA片段比对中的一个潜在缺口。
We have combined three different methods, deletion mapping of T-cell lines, field-inversion gel electrophoresis, and the restriction mapping of a cosmid clone, to construct a physical map of the murine T-cell receptor beta-chain gene family. We have mapped 19 variable (V beta) gene segments and the two clusters of diversity (D beta) and joining (J beta) gene segments and constant (C beta) genes. These members of the beta-chain gene family span approximately equal to 450 kilobases of DNA, excluding one potential gap in the DNA fragment alignments.