Magnitude of underascertainment of impaired kidney function in older adults with normal serum creatinine
Magnitude of underascertainment of impaired kidney function in older adults with normal serum creatinine
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DOI：
10.1111/j.1532-5415.2007.01196.x
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发表时间：
2007-06-01
影响因子：
6.3
通讯作者：
Guralnik, Jack M.
中科院分区：
文献类型：
--
作者：
Giannelli, Sandra V.;Patel, Kushang V.;Guralnik, Jack M.
目的：估计在社区居住的老年人群中，当血清肌酐正常的人肾小球滤过率（GFR）降低时发生的肾功能错误分类的程度，并描述与错误分类相关的参与者特征。设计：横断面。设置：意大利老年人的基于人群的研究。参与者：660名年龄在65至92岁的血清肌酐正常的参与者。测量：结果：在血清肌酐正常的受试者中，根据Cockcroft-Gault方程和肌酐清除率（CrCl）计算，分别有39%和25%的受试者有中度肾功能损害（GFR < 60 mL/min）。在65 - 74岁、75 - 84岁和85岁及以上人群中，中度肾功能损害的患病率分别为18.6%、58.3%和96.8%（趋势P
Objectives: To estimate in a community-dwelling elderly population the magnitude of renal function misclassification, occurring when persons with normal serum creatinine have reduced glomerular filtration rate (GFR), and to describe the participant characteristics related to misclassification.Design: Cross-sectional.Setting: Population-based study of older Italian people.Participants: Six hundred sixty participants aged 65 to 92 with normal serum creatinine.Measurements: GFR was estimated using the Cockcroft-Gault equation and creatinine clearance (CrCl) calculated from 24-hour urine collection.Results: In participants with normal serum creatinine, 39% and 25% had moderate renal function impairment (GFR < 60 mL/min) according to the Cockcroft-Gault equation and CrCl calculation, respectively. Prevalence of moderate renal impairment in those aged 65 to 74, 75 to 84, and 85 and older was 18.6%, 58.3%, and 96.8%, respectively (P for trend