Cyclooxygenase-2 expression is positively associated with lymph node metastasis in nasopharyngeal carcinoma.
Cyclooxygenase-2 expression is positively associated with lymph node metastasis in nasopharyngeal carcinoma.
复制标题
鼻咽癌中Cyclooxygenase-2表达与淋巴结转移呈正相关
DOI：
10.1371/journal.pone.0173641
复制
发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Yu M
中科院分区：
文献类型：
--
作者：
Yang G;Deng Q;Fan W;Zhang Z;Xu P;Tang S;Wang P;Wang J;Yu M
越来越多的证据表明，环氧合酶-2（考克斯-2）与头颈部肿瘤，尤其是鼻咽癌的发生有关。但考克斯-2表达与鼻咽癌淋巴结转移的关系尚不清楚。本系统评价和荟萃分析旨在探讨考克斯-2表达与鼻咽癌淋巴结转移及其他疾病进展体征之间的关系。截至2016年11月，在4个英文数据库和3个中文数据库（Pubmed、Embase、科克伦系统评价数据库、Web of Science、中国国家知识基础设施、万方、Vip期刊集成平台）中识别了先前发表的评估NPC中考克斯-2表达和淋巴结转移的研究。所有符合条件的研究的质量进行了评估，使用纽卡斯尔-渥太华质量评估量表（NOS）。采用固定效应或随机效应模型计算合并比值比（OR）及其95%可信区间（95%CI），评价考克斯-2表达对淋巴结转移的影响。共有27项研究（1797例NPC患者）符合纳入标准。鼻咽癌患者中考克斯-2的表达显著高于非鼻咽癌患者，合并OR为21.17（95%CI = 15.02-29.85，I2 = 35.1%，P异质性= 0.070）。考克斯-2表达与鼻咽癌淋巴结转移及其他疾病进展指标相关，OR值为4.44（95%CI = 3.46-5.70，I2 = 38.3%，P异质性= 0.024）。基于考克斯-2检测和TNM分期标准的亚组分析显示无显著异质性。结果提示，考克斯-2的表达与鼻咽癌的淋巴结转移和疾病进展有关，提示其在评估预后和治疗决策中具有潜在的作用。考克斯-2抑制剂在鼻咽癌的治疗中具有潜力，值得进一步研究。
Accumulating evidence has demonstrated that cyclooxygenase-2 (COX-2) is involved in head and neck cancers, especially in nasopharyngeal carcinoma (NPC). However, the association between COX-2 expression and lymph node metastasis in NPC remains uncertain. This systematic review and meta-analysis meta-analysis investigated the relationship between COX-2 expression and lymph node metastasis and other signs of disease progression in NPC. Previously published studies assessing COX-2 expression and lymph node metastasis in NPC were identified in four English databases and three Chinese ones (Pubmed, Embase, Cochrane Database of Systematic Reviews, Web of Science, China National Knowledge Infrastructure, Wanfang, Vip Journal Integration Platform) up to November 2016. Quality of all eligible studies was assessed using the Newcastle-Ottawa Quality Assessment Scale (NOS). Pooled odds ratios (OR) and their 95% confidence intervals (95%CI) were calculated with fixed-effects or random-effects model to evaluate the effects of COX-2 expression on lymph node metastasis. A total of 27 studies with 1797 NPC patients met the inclusion criteria. The expression of COX-2 was significantly higher in patients with nasopharyngeal carcinoma than those without the carcinoma, with a combined OR of 21.17 (95%CI = 15.02–29.85, I2 = 35.1%, Pheterogeneity = 0.070). A statistically significant association between COX-2 expression and lymph node metastasis in NPC patients, with an OR of 4.44 (95%CI = 3.46–5.70, I2 = 38.3%, Pheterogeneity = 0.024), and with other indicators of disease progression. Subgroup analyses based on COX-2 assay and staging criteria of TNM showed no significant heterogeneity. The results suggest that expression of COX-2 is associated with lymph node metastasis and disease progression in NPC, indicating a potential role in evaluation of prognosis and in treatment decisions. COX-2 inhibitors have potential in the treatment of NPC that should be further investigated.