CVS role of TRPV: from single channels to HRV assessment with Artificial Intelligence.
CVS role of TRPV: from single channels to HRV assessment with Artificial Intelligence.
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TRPV 的 CVS 作用：从单一通道到人工智能的 HRV 评估。
DOI：
10.1096/fasebj.2018.32.1_supplement.732.6
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
R. Barrett
中科院分区：
文献类型：
--
作者：
Fiona O’Brien;Bryan M. Williams;H. Pratt;R. Barrett
下丘脑室旁核（PVN）是大脑中重要的自主神经控制中心，在应激、代谢、心血管功能和体内平衡中发挥作用。已鉴定的PVN神经元直接投射到脊髓，并可通过交感神经控制来调节心血管功能，然而，其潜在机制尚未完全了解。我们小组的工作突出了TRPV4在PVN中的温度传感和温度调节中的作用。为了研究TRPV4通道是否可以在调节心血管功能中发挥作用，我们使用了体内，体外和计算机技术的组合。
The paraventricular nucleus (PVN) of the hypothalamus is an important autonomic control centre in the brain with roles in stress, metabolism, cardiovascular function and homeostasis. Identified PVN neurones project directly to the spinal cord and can modulate cardiovascular function via sympathetic control, however, the underlying mechanisms are not fully understood. Work from our group has highlighted roles for TRPV4 in osmosensing and thermoregulation in the PVN. To investigate whether TRPV4 channels may play a role in modulating cardiovascular function, we have used a combination of in vivo, in vitro and in silico techniques.