Levels of angiogenesis-related vascular endothelial growth factor family in neovascular glaucoma eyes
Levels of angiogenesis-related vascular endothelial growth factor family in neovascular glaucoma eyes
复制标题
新生血管性青光眼眼血管生成相关血管内皮生长因子家族的水平
DOI：
10.1111/aos.12624
复制
发表时间：
2015-11-01
影响因子：
3.4
通讯作者：
Zhang, Xiulan
中科院分区：
文献类型：
--
作者：
Chen, Shida;Zhou, Minwen;Zhang, Xiulan
PurposeThis study aims to evaluate the angiogenesis-related factors of the vascular endothelial growth factor（VEGF）family in the aqueous humor of patients with neovascularglaucoma（NVG.MethodsThis study involved 22 eyes of 22 patients with advanced NVG requiring anticancomatous surgery and 20 control subjects with cataracids. NVG眼在抗青光眼手术前接受玻璃体内注射雷珠单抗（IVR）治疗。在IVR和白内障手术时采集房水和血液。用ELISA法检测房水和血浆中VEGF-A、VEGF-B和胎盘生长因子（PlGF）的蛋白浓度。NVG患者房水中VEGF-A和PlGF的标准差分别为3037（2387）pg/ml和1078（712）pg/ml;结论NVG患者眼房水中除VEGF-B外，均含有较高浓度的VEGF家族血管生成因子，且VEGF-A与PlGF呈正相关。NVG患者中的高PlGF水平可能为治疗NVG提供另一个潜在的靶点。
PurposeThis study aimed to evaluate the angiogenesis-related factors of the vascular endothelial growth factor (VEGF) family in the aqueous humour of patients with neovascular glaucoma (NVG).MethodsThis study involved 22 eyes of 22 patients with advanced NVG requiring antiglaucomatous surgery and 20 control subjects with cataracts. The NVG eyes received an intravitreal injection of ranibizumab (IVR) treatment before antiglaucomatous surgery. Aqueous humour and blood were collected at the time of IVR and cataract surgery. Protein concentration of VEGF-A, VEGF-B and placenta growth factor (PlGF) in aqueous humour and plasma was determined by ELISA tests.ResultsThe mean concentration (standard deviation) of VEGF-A and PlGF in the aqueous humour of patients with NVG were 3037 (2387) pg/ml and 1078 (712) pg/ml, respectively; both were significantly higher than the control group (both p0.05).ConclusionThere were high concentrations of angiogenesis factors of the VEGF family, with the exception of VEGF-B, in the aqueous humour of patients with NVG, and there was a positive correlation between VEGF-A and PlGF. High PlGF levels in patients with NVG may provide another potential target for treatment of NVG.