Is fasting insulin concentration inversely associated with rate of weight gain? Contrasting findings from the CARDIA and ARIC study cohorts
Is fasting insulin concentration inversely associated with rate of weight gain? Contrasting findings from the CARDIA and ARIC study cohorts
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DOI：
10.1038/sj.ijo.0800542
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发表时间：
1998-01-01
影响因子：
4.9
通讯作者：
Wagenknecht, LE
中科院分区：
文献类型：
--
作者：
Folsom, AR;Vitelli, LL;Wagenknecht, LE
目的：测试较高的空腹胰岛素浓度是否与6 - 7年内较低的体重增加率相关。设计：两个纵向流行病学队列，包括黑人和白人。对象：青年冠状动脉风险发展（CARDIA）研究在1985-86年和1992-93年调查了18-30岁的受试者（n = 3636），社区动脉粥样硬化风险（ARIC）研究在1987-89年和1993-95年调查了45-64岁的受试者（n = 11179）。测量：在每项研究中，对无糖尿病参与者的基线空腹胰岛素和随访期间的体重变化进行测量。结果：在CARDIA的白人和黑人男性中，基线胰岛素和体重变化之间存在年龄调整正相关，尽管体重变化在胰岛素四分位数中并非完全单调。在这些种族-性别组中，线性回归系数表明，基线胰岛素每增加50 pmol/L，体重增加率就会增加约0.10 kg/y（95%置信区间（CI），以kg/y计算，白人女性为0.023-0.187，黑人男性为0.015-0.150，白人男性为0.011-0.158）。通过调整基线体重，这种关联完全消除了。相比之下，在ARIC的白人和黑人女性中，相关性为负，线性回归系数表明，空腹胰岛素浓度每提高50 pmol/L，体重增加率就会降低0.03-0.10 kg/y （kg/y估计的95% CI为黑人女性-0.133至-0.061，白人女性-0.106至-0.054，白人男性-0.055至-0.009）。这一发现通常通过调整基线体重指数（BMI）得到加强。结论：较高的空腹胰岛素浓度与ARIC中较低的体重增加率相关，但与CARDIA无关。
OBJECTlVE: To test whether a higher fasting insulin concentration is associated with a lower rate of weight gain over six to seven years.DESIGN: Two longitudinal epidemiologic cohorts including blacks and whites.SUBJECTS: The Coronary Artery Risk Development in Young Adults (CARDIA) Study examined subjects aged 18-30 y in 1985-86 and 1992-93 (n = 3636), and the Atherosclerosis Risk in Communities (ARIC) Study examined subjects aged 45-64 y in 1987-89 and 1993-95 (n = 11179).MEASUREMENTS: In each study, fasting insulin at baseline and weight change during follow-up were measured in participants without diabetes.RESULTS: In whites and black men in CARDIA, there was a positive age-adjusted association between baseline insulin and weight change, although weight change was not entirely monotonic across the insulin quartiles. In these race-gender-groups, the linear regression coefficients indicated that each 50 pmol/L increment of baseline insulin was associated (P < 0.05) with approximately 0.10 kg/y greater rate of weight gain (95% confidence intervals (CI) for this estimate in kg/y were 0.023-0.187 for white women, 0.015-0.150 for black men, and 0.011-0.158 for white men). The association was eliminated entirely with adjustment for baseline weight. In contrast, among whites and black women in ARIC, the association was negative, with the linear regression coefficients suggesting that each 50 pmol/L higher fasting insulin concentration was associated (P < 0.05) with a 0.03-0.10 kg/y lower rate of weight gain (95% CI for this estimate in kg/y were -0.133 to -0.061 for black women, -0.106 to -0.054 for white women, and -0.055 to -0.009 for white men). This finding was generally strengthened by adjustment for baseline body mass index (BMI).CONCLUSIONS: A higher fasting insulin concentration is associated modestly with a lower rate of weight gain in ARIC, but not in CARDIA.