New bisindole alkaloids of the topsentin and hamacanthin classes from the Mediterranean marine sponge Rhaphisia lacazei
New bisindole alkaloids of the topsentin and hamacanthin classes from the Mediterranean marine sponge Rhaphisia lacazei
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DOI：
10.1021/np9903292
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发表时间：
2000-04-01
影响因子：
5.1
通讯作者：
Riccio, R
中科院分区：
文献类型：
--
作者：
Casapullo, A;Bifulco, G;Riccio, R
对海绵Rhaphisia Lacazei的Et2O提取物进行化学研究，分离出13种纯双吲哚生物碱（1-13）。化合物（1-6）属于植物素类，已经被描述过。化合物7 ~ 13为新产物，与哈马卡纳素类密切相关。主要化合物1 ~ 3体外抗肿瘤活性测定；化合物2和3对人支气管肺癌细胞（NSCLC-NG）具有抗增殖活性，IC50分别为12和6.3 μ g/mL。
Chemical investigation of the Et2O extract of the marine sponge Rhaphisia Lacazei resulted in the isolation of 13 pure bisindole alkaloids (1-13). Compounds (1-6) belong to the class of topsentins and have already been described. Compounds 7-13 are new products, closely related to the class of hamacanthins. The major compounds 1-3 were tested in vitro for antitumor activity; compounds 2 and 3 showed antiproliferative activity against human broncopulmonary cancer cells (NSCLC-NG) with an IC50 of 12 and 6.3 mu g/mL, respectively.