The origin of alkanes found in human skin surface lipids.
The origin of alkanes found in human skin surface lipids.
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烷烃的起源存在于人体皮肤表面脂质中。
DOI：
10.1111/1523-1747.ep12284393
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Downing,DT
中科院分区：
文献类型：
--
作者：
Bortz,JT;Wertz,PW;Downing,DT
从人体皮肤中提取的脂质含有不同量的石蜡烃。虽然这些烷烃的组成与石油蜡非常相似，但有人提出它们是人类皮肤的生物合成产物。为了探讨这个问题，从15个正常人的皮肤表面脂质的烷烃的量和组成进行了分析，使用定量薄层色谱和石英毛细管气相色谱。发现烷烃构成皮肤脂质的0.5%至1.7%。受试者在15至35个碳原子之间的烷烃链长分布以及正构烷烃（如石油蜡中的正构烷烃）和支链烷烃（如石油润滑油中的正构烷烃）的相对量方面存在很大差异。在6名受试者中，检查了来自每只耳朵的耳垢的烷烃含量，以调查烷烃是否通过全身途径或通过与环境表面直接接触到达皮肤表面。在12个耳垢样本中，有11个没有发现烷烃的痕迹。使用串联加速器质谱仪进行碳-14测年，发现皮肤表面烷烃的组合样品的理论年龄为30，950年，与矿脂样品的理论年龄相似。这些分析表明，在人体皮肤表面发现的烷烃是各种石油蒸馏馏分的混合物，这些馏分是通过环境直接污染获得的。
Lipids extracted from human skin contain variable amounts of paraffin hydrocarbons. Although the composition of these alkanes strongly resembles petroleum waxes, it has been proposed that they are biosynthetic products of human skin. To investigate this question, skin surface lipids from 15 normal subjects were analyzed for the amount and composition of alkanes, using quantitative thin-layer chromatography and quarts capillary gas chromatography. The alkanes were found to constitute 0.5% to 1.7% of the skin lipids. Subjects differed greatly in the chain length distribution of their alkanes between 15 and 35 carbon atoms, and in the relative amounts of normal alkanes (like those in petroleum waxes) and branched chain alkanes (like those in petroleum lubricating oils). In 6 subjects, the alkane content of cerumen from each ear was examined to investigate whether alkanes arrive at the skin surface by a systemic route or by direct contract with environmental surfaces. No trace of alkanes was found in 11 of the 12 cerumen samples. Using a tandem accelerator mass spectrometer for carbon-14 dating, a combined sample of the skin surface alkanes was found to have a theoretical age of 30,950 years, similar to that of a sample of petrolatum. These analyses indicate that the alkanes found on the surface of human skin are mixtures of a variety of petroleum distillation fractions that are acquired by direct contamination from the environment.