Correlation of circulating CD27high plasma cells and disease activity in systemic lupus erythematosus
Correlation of circulating CD27high plasma cells and disease activity in systemic lupus erythematosus
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DOI：
10.1191/0961203304lu1014oa
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发表时间：
2004-01-01
期刊：
影响因子：
2.6
通讯作者：
Lipsky, P
中科院分区：
文献类型：
--
作者：
Dörner, T;Lipsky, P
CD27可一步鉴定主要B细胞亚群、CD27(-)幼稚记忆性B细胞、CD27(+)记忆性B细胞以及CD27(高)浆细胞，是评估循环B细胞和B细胞亚群数量的有用标记物。CD27(+)B细胞亚群分布异常有助于评估系统性红斑狼疮(SLE)患者的疾病活动性。特别是，在SLE儿童和成人中，CD27(高)浆细胞的频率与狼疮活动显著相关。传统的免疫抑制疗法影响CD27(-)初始B细胞和CD27(高)浆细胞的数量，但不针对CD27(+)记忆B细胞。这些结果表明，疾病暴发可能与常规免疫抑制治疗后CD27(+)记忆B细胞的保留有关，而针对这些细胞的新疗法可能提供新的机会来诱导SLE的缓解。
CD27 is a useful marker in assessing the number of circulating B cells and B cell subsets because it permits one step identification of the major B cell compartments, CD27(-) naive and CD27(+) memory B cells as well as CD27(high) plasma cells. Abnormalities in the distribution of CD27(+) B cell subsets are useful in assessing disease activity in patients with systemic lupus erythematosus (SLE). In particular, the frequency of CD27(high) plasma cells significantly correlates with lupus activity in both children and adults with SLE. Conventional immuno suppressive therapies affect the number of CD27(-) naive B cells and CD27(high) plasma cells, but do not target CD27(+) memory B cells. These results suggest that disease flares may relate to the retention of CD27(+) memory B cells after conventional immuno suppressive therapy and that new therapies that target these cells specifically may offer new opportunities to induce remission in SLE.