Cytotoxic T lymphocyte and cDNA sequence analyses of the MHC class Ib molecule Qa1 in nonobese diabetic mice.
Cytotoxic T lymphocyte and cDNA sequence analyses of the MHC class Ib molecule Qa1 in nonobese diabetic mice.
复制标题
非肥胖糖尿病小鼠中 MHC Ib 类分子 Qa1 的细胞毒性 T 淋巴细胞和 cDNA 序列分析。
DOI：
10.1007/s002510100357
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Aldrich,CJ
中科院分区：
文献类型：
--
作者：
Chun,T;Hermel,E;Gaskins,HR;Aldrich,CJ
507 ity of normal targets (Brooks et al. 1997). CD94/NKG2A receptors may also serve as T-cell inhibitory receptors by down-regulation of cell-mediated lympholysis (CML) restricted by class Ia molecules (Lohwasser et al. 2001). Together, these data imply an important role for a Qa1-restricted immune response in triggering or progression of autoimmunity.Previously, we identified a peptide derived from the leader sequence of preproinsulin that binds to Qa1b and is recognized by Qa1b-restricted cytotoxic T lymphocytes (CTLs)(Chun et al. 1998). Similar to this observation, others have shown that Qa1 presents additional insulin-derived peptides via an unusual Tap-independent presentation of soluble antigens (Tompkins et al. 1998). However, the functional role of Qa1 in the mouse model of autoimmune diabetes has not been explored. To better understand NOD immunopathology, and a possible role for Qa1 in autoimmune diabetes, we examined Qa1 expression on NOD and normal pancreatic β-cell lines and splenocytes.
