Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood:: ISAAC Phases One and Three repeat multicountry cross-sectional surveys
Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood:: ISAAC Phases One and Three repeat multicountry cross-sectional surveys
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DOI：
10.1016/s0140-6736(06)69283-0
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发表时间：
2006-08-01
期刊：
影响因子：
168.9
通讯作者：
Williams, Hywel
中科院分区：
文献类型：
--
作者：
Asher, M. Innes;Montefort, Stephen;Williams, Hywel
哮喘、过敏性鼻结膜炎和湿疹患病率随时间变化趋势的数据很少。我们重复的国际研究哮喘和过敏儿童（ISAAC）至少5年后，第一阶段，以检查这些disorders.Methods的症状患病率的变化ISAAC第三阶段研究，在2002年和2003年之间，我们做了一个横断面问卷调查，193 404名6-7岁的儿童从66个中心在37个国家，和304 679名儿童年龄在13-14岁，从106个中心在56个国家，从随机抽样的学校在一个确定的地理区域。大多数中心显示，至少一种疾病的1种或多种SE患病率发生变化，增加是减少的两倍，6-7岁年龄组的增加比13-14岁年龄组更常见，并且在大多数平均患病率水平下。一个例外是老年组的哮喘症状，在高流行率下，哮喘症状的减少更为常见。对于这两个年龄组，更多的中心表现出增加，在所有三种疾病往往比显示减少，但大多数中心有混合的changes.Interpretation症状的患病率在许多中心的上升是令人担忧的，但没有增加哮喘症状的患病率与现有的高患病率在老年组的中心是令人放心的。过敏性疾病症状流行的不同趋势构成了进一步研究此类疾病原因的基础。
Background Data for trends in prevalence of asthma, allergic rhinoconjunctivitis, and eczema over time are scarce. We repeated the International Study of Asthma and Allergies in Childhood (ISAAC) at least 5 years after Phase One, to examine changes in the prevalence of symptoms of these disorders.Methods For the ISAAC Phase Three study, between 2002 and 2003, we did a cross-sectional questionnaire survey of 193 404 children aged 6-7 years from 66 centres in 37 countries, and 304 679 children aged 13-14 years from 106 centres in 56 countries, chosen from a random sample of schools in a defined geographical area.Findings Phase Three was completed a mean of 7 years after Phase One. Most centres showed a change in prevalence of 1 or more SE for at least one disorder, with increases being twice as common as decreases, and increases being more common in the 6-7 year age-group than in the 13-14 year age-group, and at most levels of mean prevalence. An exception was asthma symptoms in the older age-group, in which decreases were more common at high prevalence. For both age-groups, more centres showed increases in all three disorders more often than showing decreases, but most centres had mixed changes.Interpretation The rise in prevalence of symptoms in many centres is concerning, but the absence of increases in prevalence of asthma symptoms for centres with existing high prevalence in the older age-group is reassuring. The divergent trends in prevalence of symptoms of allergic diseases form the basis for further research into the causes of such disorders.