Role of Autophagy in the Maintenance of Intestinal Homeostasis.
Role of Autophagy in the Maintenance of Intestinal Homeostasis.
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DOI：
10.1053/j.gastro.2015.06.046
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发表时间：
2015-09
期刊：
影响因子：
29.4
通讯作者：
Xavier RJ
中科院分区：
文献类型：
--
作者：
Baxt LA;Xavier RJ
炎症性肠病的全基因组关联研究已经在调节自噬的基因中发现了几个风险基因，研究为这些多态的功能影响提供了洞察力。我们回顾了自噬促进肠道稳态的机制，重点介绍了自噬在调节肠道生态、限制病原菌和控制炎症方面的特定细胞类型的作用。基于这些信息，我们开始了解自噬的变化如何导致肠道炎症。
Genome-wide association studies of inflammatory bowel disease have identified several risk loci in genes that regulate autophagy, and studies have provided insight into the functional effects of these polymorphisms. We review the mechanisms by which autophagy contributes to intestinal homeostasis, focusing on its cell type-specific roles in regulating gut ecology, restricting pathogenic bacteria, and controlling inflammation. Based on this information, we are beginning to understand how alterations in autophagy can contribute to intestinal inflammation.