Convergence of excitatory and inhibitory hair cell transmitters shapes vestibular afferent responses
Convergence of excitatory and inhibitory hair cell transmitters shapes vestibular afferent responses
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DOI：
10.1073/pnas.0402824101
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发表时间：
2004-11-02
影响因子：
11.1
通讯作者：
Highstein, SM
中科院分区：
文献类型：
--
作者：
Holstein, GR;Rabbitt, RD;Highstein, SM
前庭半规管对角加速度作出响应，角加速度通过管的生物流体力学积分到角速度，并且是编码速度的传入响应的主要来源。令人惊讶的是，一些传入神经实际上报告了角加速度。我们的数据表明，毛细胞/传入突触在这些传入神经中引入了数学导数，部分取消了生物力学积分并导致编码角加速度的放电速率。我们研究了毛细胞的会聚突触输入对这种数学分化的作用。在施用γ-氨基丁酸B型受体拮抗剂后，观察到低频刺激的分化顺序显着降低。结果表明，γ-氨基丁酸参与塑造传入反应的时间动态。
The vestibular semicircular canals respond to angular acceleration that is integrated to angular velocity by the biofluid mechanics of the canals and is the primary origin of afferent responses encoding velocity. Surprisingly, some afferents actually report angular acceleration. Our data indicate that hair-cell/afferent synapses introduce a mathematical derivative in these afferents that partially cancels the biomechanical integration and results in discharge rates encoding angular acceleration. We examined the role of convergent synaptic inputs from hair cells to this mathematical differentiation. A significant reduction in the order of the differentiation was observed for low-frequency stimuli after gamma-aminobutyric acid type B receptor antagonist administration. Results demonstrate that gamma-aminobutyric acid participates in shaping the temporal dynamics of afferent responses.