Nd3+ doped LuOF nanophosphors for bimodality imaging of NIR-to-NIR-II luminescence and X-Ray computed tomography
Nd3+ doped LuOF nanophosphors for bimodality imaging of NIR-to-NIR-II luminescence and X-Ray computed tomography
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DOI：
10.1016/j.jlumin.2020.117753
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发表时间：
2020-11
影响因子：
3.6
通讯作者：
Zhenfeng Yu;Xiao-yan Fu;Shenghui Zheng;Hongwu Zhang
中科院分区：
文献类型：
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作者：
Zhenfeng Yu;Xiao-yan Fu;Shenghui Zheng;Hongwu Zhang
本文设计了双模显像剂LuOF: Nd3+NPs，可以提供NIR-to-NIR-II发光和x射线计算机断层扫描的双模成像。水热法制备的样品具有不规则的铺路石形状，尺寸分布在10 ~ 15 nm之间。结构分析表明，样品为纯立方相。在808 nm激光（功率为500mW/cm2）激发下，Lu0.99OF: 0.01Nd3+NPs表现出优异的NIR- ii发光，主峰位于1053 nm，近红外发射强度达到3.0 × 105 cps。同时，当Lu0.99OF: 0.01Nd3+NPs含量仅为10 mg/mL时，x射线衰减值为100HU。MTT阵列证实了Lu0.99OF: 0.01Nd3+NPs具有良好的生物安全性。此外，他们的体内成像结果证实了Lu0.99OF: 0.01Nd3+NPs不仅具有NIR-II发光深部组织体内成像能力，而且具有良好的计算机断层成像能力。这些结果表明，LuOF: Nd3+NPs在未来的医学领域可以作为双模显像剂。
In this paper, we have designed dual-mode imaging agents LuOF: Nd3+NPs, which can provided bimodality imaging of NIR-to-NIR-II luminescence and X-Ray computed tomography. The as-prepared samples prepared by hydrothermal method possessed irregular paving stone shapes with size distribution of 10–15 nm. The structure analysis showed the samples were pure cubic phase. Under the excitation of 808 nm laser (power of 500mW/cm2), Lu0.99OF: 0.01Nd3+NPs exhibited excellent NIR-II luminescence, which main peak located at 1053 nm and NIR emission intensity reached 3.0 × 105 cps. At the same time, the X-ray attenuation value was 100HU when the content of Lu0.99OF: 0.01Nd3+NPs was only 10 mg/mL. And, the MTT arrays have confirmed the excellent biological safety of Lu0.99OF: 0.01Nd3+NPs. Furthermore, thein vivoimaging results have confirmed that Lu0.99OF: 0.01Nd3+NPs possessed not only NIR–II luminescent deep tissuein vivoimaging ability but also good computed tomography imaging ability. All these results indicated that LuOF: Nd3+NPs can be regarded as dual-mode imaging agents in future medical field.