Effect of Lactobacillus plantarum 299v on cardiovascular disease risk factors in smokers
Effect of Lactobacillus plantarum 299v on cardiovascular disease risk factors in smokers
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DOI：
10.1093/ajcn/76.6.1249
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发表时间：
2002-12-01
影响因子：
7.1
通讯作者：
Bukowska, H
中科院分区：
文献类型：
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作者：
Naruszewicz, M;Johansson, ML;Bukowska, H
背景资料：通过纤维的细菌发酵在人类结肠中形成的短链脂肪酸可能具有抑制作用，可能减少胰岛素的产生，并且可能改善脂质代谢。我们以前表明，在高胆固醇血症患者中，补充益生菌植物乳杆菌299 v显着降低LDL胆固醇和纤维蛋白原的浓度。设计：36名健康志愿者（18名女性和18名男性），年龄35-45岁，参加了一项对照、随机、双盲试验。实验组每天饮用含L. plantarum 299 v（5 X 10（7）菌落形成单位/mL）;对照组消耗相同体积的不含细菌的产品。结果：实验组收缩压（P < 0.000）、瘦素（P <0.000）、纤维蛋白原（P < 0.001）均明显下降。在对照组中未观察到此类变化。与基线相比，在实验组中还观察到F-2-异前列腺素（37%）和白细胞介素6（42%）降低。从用L. plantarum对人脐静脉内皮细胞的粘附能力显著降低（P < 0.001）。植物药给药导致心血管疾病危险因素的减少，并可用作吸烟者动脉粥样硬化的初级预防中的保护剂。
Background: The short-chain fatty acids formed in the human colon by the bacterial fermentation of fiber may have an antiinflammatory effect, may reduce insulin production, and may improve lipid metabolism. We previously showed in hypercholesterolemic patients that supplementation with the probiotic bacteria Lactobacillus plantarum 299v significantly lowers concentrations of LDL cholesterol and fibrinogen.Objective: We determined the influence of a functional food product containing L. plantarum 299v on lipid profiles, inflammatory markers, and monocyte function in heavy smokers.Design: Thirty-six healthy volunteers (18 women and 18 men) aged 35-45 y participated in a controlled, randomized, double-blind trial. The experimental group drank 400 mL/d of a rose-hip drink containing L. plantarum 299v (5 X 10(7) colony-forming units/mL); the control group consumed the same volume of product without bacteria. The experiment lasted 6 wk and entailed no changes in lifestyle.Results: Significant decreases in systolic blood pressure (P < 0.000), leptin (P < 0.000), and fibrinogen (P < 0.001) were recorded in the experimental group. No such changes were observed in the control group. Decreases in F-2-isoprostanes (37%) and interleukin 6 (42%) were also noted in the experimental group in comparison with baseline. Monocytes isolated from subjects treated with L. plantarum showed significantly reduced adhesion (P < 0.001) to native and stimulated human umbilical vein endothelial cells.Conclusion: L. plantarum administration leads to a reduction in cardiovascular disease risk factors and could be useful as a protective agent in the primary prevention of atherosclerosis in smokers.