The association of interleukin-18 genotype and serum levels with metabolic risk factors for cardiovascular disease
The association of interleukin-18 genotype and serum levels with metabolic risk factors for cardiovascular disease
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DOI：
10.1530/eje-07-0463
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发表时间：
2007-11-01
影响因子：
5.8
通讯作者：
Goedecke, Julia H.
中科院分区：
文献类型：
--
作者：
Evans, Juliet;Collins, Malcolm;Goedecke, Julia H.
目的：循环中IL-18水平与代谢综合征和心血管疾病(CVD)的发生风险相关。本研究调查了正常体重和肥胖的南非黑人妇女循环中IL-18水平和IL-18基因-137 G/C多态性与心血管疾病代谢危险因素的关系。方法：血压(BP)、体成分(双能X线吸收测量仪)、内脏肥胖(计算机断层扫描)以及空腹血糖、胰岛素、血脂、IL-18水平，对104例正常体重(体重指数：2.5 kg/m2)和124例肥胖(体重指数3.0 kg/m-2)南非黑人妇女进行了IL-18和IL-18基因分型。结果：GC型平均动脉压(MAP，90.6±11.1vs85.5+/-1.0.3 mm Hg，P
Objective: Circulating levels of interleukin (IL)- 18 are associated with the metabolic syndrome and risk for the development of cardiovascular disease (CVD). This study investigated the association between the circulating IL-18 levels and the - 137 G/C polymorphism within the IL-18 gene with metabolic risk factors for CVD in normal-weight and obese black South African women.Methods: Blood pressure (BP), body composition (dual-energy X-ray absorptiometer), visceral adiposity (computerized tomography), as well as fasting glucose, insulin, lipid profile, IL-18 levels, and IL-18 genotype were measured in 104 normal-weight (body mass index (BMI) :! 2 5 kg/m 2) and 124 obese (BMI 3 0 kg /M-2) black South African women.Results: Subjects with a GC genotype (23%) had a greater mean arterial pressure (MAP, 90.6 11.1 vs 85.5 +/- 1.0.3 mmHg, P