Semimetal nanomaterials of antimony as highly efficient agent for photoacoustic imaging and photothermal therapy.
Semimetal nanomaterials of antimony as highly efficient agent for photoacoustic imaging and photothermal therapy.
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锑半金属纳米材料作为光声成像和光热治疗的高效剂
DOI：
10.1016/j.biomaterials.2014.12.037
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发表时间：
2015-03
期刊：
影响因子：
14
通讯作者：
Chen X
中科院分区：
文献类型：
--
作者：
Li W;Rong P;Yang K;Huang P;Sun K;Chen X
在这项研究中，我们报道了半金属纳米材料锑(Sb)作为光声成像(PAI)和光热治疗(PTT)的高效试剂。以十八烷(ODE)和油胺(OAM)为溶剂，通过简单的方法合成了Sb纳米棒束。聚乙二醇化的Sb纳米粒子在紫外光(UV)和近红外(NIR)波长范围内具有广泛而强烈的光吸收，适合作为808 nm激光驱动的光热剂，其光热转换效率高达41%，显著高于已报道的大多数PTT试剂。我们的体外实验还表明，聚乙二醇化的Sb纳米颗粒对癌细胞的消融作用依赖于激光功率。瘤内注射聚乙二醇化的Sb纳米粒子，用1W/cm2的低功率近红外激光照射5min(或0.5W/cm2照射10min)可实现100%的肿瘤消融，且光热治疗后未发现明显的毒副作用。此外，瘤内注射聚乙二醇化锑纳米颗粒和近红外激光照射后，由于其较强的近红外光吸收，也观察到了强烈的PA信号，这表明聚乙二醇化锑纳米颗粒是一种潜在的近红外PA试剂。基于本工作的发现，可以进一步开发利用其他单金属纳米晶体作为高效的近红外试剂来进行活体肿瘤成像和PTT。
In this study we report semimetal naonmaterials of antimony (Sb) as highly efficient agent for photoacoustic imaging (PAI) and photothermal therapy (PTT). The Sb nanorod bundles have been synthesized through a facile route by mixing 1-octadecane (ODE) and oleyl amine (OAm) as the solvent. The aqueous dispersion of PEGylated Sb NPs, due to its broad and strong photoabsorption ranging from ultraviolet (UV) to near-infrared (NIR) wavelengths, is applicable as a photothermal agent driven by 808 nm laser with photothermal conversion efficiency up to 41%, noticeably higher than most of the PTT agents reported before. Our in vitro experiments also showed that cancer cell ablation effect of PEGylated Sb NPs was dependent on laser power. By intratumoral administration of PEGylated Sb NPs, 100% tumor ablation can be realized by using NIR laser irradiation with a lower power of 1 W/cm2 for 5 min (or 0.5 W/cm2 for 10 min) and no obvious toxic side effect is identified after photothermal treatment. Moreover, intense PA signal was also observed after intratumoral injection of PEGylated Sb NPs and NIR laser irradiation due to their strong NIR photoabsorption, suggesting PEGylated Sb NPs as a potential NIR PA agent. Based on the findings of this work, futher development of using other smimetal nanocrystals as highly efficient NIR agents can be achieved for vivo tumor imaging and PTT.