Biochemical activities and electronic spectra of different cobalt phenanthroline complexes
Biochemical activities and electronic spectra of different cobalt phenanthroline complexes
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DOI：
10.1016/j.arabjc.2018.11.006
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发表时间：
2019-11-01
影响因子：
6
通讯作者：
Al-Omair, Mohammed A.
中科院分区：
文献类型：
--
作者：
Al-Omair, Mohammed A.
合成了一系列八面体邻菲咯啉氯化钴、水和碳酸盐配合物，并对其进行了表征，从区域抑制率和最低抑菌浓度两个方面详细研究了它们的抗菌活性。通过测定DPPH、SOD和ABTS自由基清除活性来研究它们的抗氧化活性。结果表明，邻菲咯啉碳酸钴配合物具有最高的抗菌活性、抗氧化活性和对DNA的降解作用，对肝细胞癌(HEPG-2)、乳腺癌细胞(MCF-7)和结肠癌(HCT-116)细胞表现出中等的细胞毒性，并用紫外光谱研究了溶剂对电子光谱的影响。用多元回归技术对峰位置与溶剂参数之间的关系方程进行了计算机分析，并计算了相关系数和回归系数。所用的独立溶剂参数是氢键能力、折射率和介电常数。根据实际结构对红外光谱进行了解释。(C)2018年由爱思唯尔B.V.制作和主办。
A series of octahedral phenanthroline cobalt chlorides, aqua and carbonates complexes have been prepared, characterized, and their antibacterial activity was studied in detail in terms of zone inhibition and minimum inhibitory concentrations. Their antioxidant activities were studied by measuring DPPH, SOD and ABTS radical scavenging activity. It was found that cobalt phenanthroline carbonate complex possessed highest antibacterial activity, antioxidant activity, degradation effect on DNA and showed moderate cytotoxicity against Hepatocellular carcinoma (HEPG-2), Mammary gland (MCF-7) and Colorectal carcinoma (HCT-116) cells.The complexes were studied with UV spectroscopy to observe the solvents effect on the electronic spectra. Equation that relates peak position lambda max to solvent parameters are solved by computerized analysis using multiple regression techniques, and the correlation and regression coefficients were evaluated. The independent solvent parameters used are H-bonding ability, refractive index and dielectric constant. The FTIR spectrum was interpreted according to the actual structure. (C) 2018 Production and hosting by Elsevier B.V.