Genomics and the immune system.
Genomics and the immune system.
复制标题
基因组学和免疫系统。
DOI：
10.1111/j.1365-2567.2008.02818.x
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发表时间：
2008
期刊：
影响因子：
6.4
通讯作者：
Monticelli,Silvia
中科院分区：
文献类型：
--
作者：
Pipkin,MatthewE;Monticelli,Silvia
虽然基因组沃森-克里克碱基配对编码的遗传信息在给定个体内基本上是静态的，但对这些信息的访问是由动态机制控制的。人类基因组被广泛转录，但大多数非蛋白质编码基因组序列所起的作用仍然很大程度上是未知的。在这篇综述中，我们将重点关注基因转录调控的见解，特别强调全基因组方法，以及来自基因组全局转录的非编码rna如何反过来控制基因表达。我们回顾了该领域的最新进展，重点介绍了免疫系统。
While the hereditary information encoded in the Watson–Crick base pairing of genomes is largely static within a given individual, access to this information is controlled by dynamic mechanisms. The human genome is pervasively transcribed, but the roles played by the majority of the non‐protein‐coding genome sequences are still largely unknown. In this review we focus on insights to gene transcriptional regulation by placing special emphasis on genome‐wide approaches, and on how non‐coding RNAs, which derive from global transcription of the genome, in turn control gene expression. We review recent progress in the field with highlights on the immune system.