The effects of nasal irritant induced responses on breathing and cough in anaesthetized and conscious animal models
The effects of nasal irritant induced responses on breathing and cough in anaesthetized and conscious animal models
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DOI：
10.1016/j.resp.2013.08.003
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发表时间：
2013-12-01
影响因子：
2.3
通讯作者：
Plevkova, J.
中科院分区：
文献类型：
--
作者：
Biringerova, Z.;Gavliakova, S.;Plevkova, J.
几乎没有证据支持鼻子咳嗽的抑制作用。用生理盐水、1% DMSO、异硫氰酸烯丙酯（TRPA1激动剂）和异硫氰酸烯丙酯+AP-18 （TRPA1拮抗剂）对麻醉和清醒豚鼠进行鼻腔预处理，研究其对柠檬酸（CA）的咳嗽反应。麻醉动物气管灌注中加入柠檬酸（CA），清醒动物吸入0.4 M CA诱导咳嗽。根据剂量反应曲线、气流轨迹和咳嗽声分析统计咳嗽反应。在清醒的动物中，鼻用异硫氰酸烯丙基酯诱导可重复的剂量依赖性鼻症状和呼吸速率的显著下降。异硫氰酸烯丙基鼻灌胃后，CA诱导的咳嗽得到抑制
There is little evidence to support the down-regulation of coughing from the nose. The cough response to citric acid (CA) was studied in anesthetized and conscious guinea pigs after nasal pretreatment with saline, 1% DMSO, allylisothiocyanate (TRPA1 agonist) and allylisothiocyanate +AP-18 (TRPA1 antagonist). Cough was induced by adding citric acid (CA) to the tracheal perfusion in anaesthetized animals, or by inhaling 0.4 M CA in conscious animals. The cough response was counted from the dose response curves, airflow traces and cough sound analysis.In conscious animals, nasal allylisothiocyanate induced reproducible, dose dependent nasal symptoms and a significant drop in respiratory rate. Cough induced by CA was suppressed after nasal allylisothiocyanate (p