Complementary RNAs in Paramyxovirions and Paramyxovirus-infected Cells
Complementary RNAs in Paramyxovirions and Paramyxovirus-infected Cells
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副粘病毒颗粒和副粘病毒感染细胞中的互补 RNA
DOI：
10.1038/2281196a0
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发表时间：
1970
期刊：
影响因子：
64.8
通讯作者：
D. Kingsbury
中科院分区：
文献类型：
--
作者：
A. Portner;D. Kingsbury
新城疫病毒和仙台病毒可以诱导感染细胞合成单链RNA，这种单链RNA的沉积速度比病毒粒子慢，并且在核苷酸序列上与病毒粒子4-6互补。人们对这些互补RNA的兴趣源于它们作为病毒蛋白模板的可能性。对于一些RNA病毒来说，很明显，病毒基因组是信息7-10；但对于副粘病毒，基因组可能包含很少或根本不包含可以直接翻译的遗传信息。副粘病毒似乎并不是独一无二的：水疱性口炎病毒(VSV)指导合成比病毒RNA小并与其11、12互补的RNA。
PARAMYXOVIRIONS contain single-stranded RNAs sedimenting at 50–57S1–3, Newcastle disease virus (NDV) and Sendai virus have been shown to induce infected cells to synthesize single-stranded RNAs which sediment more slowly than virion RNAs and are complementary to them in nucleotide sequences4–6. Interest in these complementary RNAs derives from the possibility that they are templates for viral proteins. For some RNA viruses it is clear that the viral genome is the message7–10; but for paramyxoviruses, the genome may contain little or no genetic information that can be translated directly. Paramyxoviruses do not seem to be unique: vesicular stomatitis virus (VSV) directs the synthesis of RNAs smaller than virion RNA and complementary to it11,12.