Mesenchymal Stem Cells, Osteoblasts and Extracellular Matrix Proteins: Enhancing Cell Adhesion and Differentiation for Bone Tissue Engineering
Mesenchymal Stem Cells, Osteoblasts and Extracellular Matrix Proteins: Enhancing Cell Adhesion and Differentiation for Bone Tissue Engineering
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DOI：
10.1089/ten.teb.2009.0714
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发表时间：
2010-08-01
影响因子：
6.4
通讯作者：
Cartmell, Sarah H.
中科院分区：
文献类型：
--
作者：
Hidalgo-Bastida, Lilia Araida;Cartmell, Sarah H.
细胞与支架的黏附一直是组织工程领域面临的挑战之一。虽然蛋白质表面修饰已被证明可以增强细胞的粘附性和保持性，但其特异性取决于细胞和生物材料类型，这意味着必须为每种特定的应用确定最佳的蛋白质和浓度。本文综述了利用成骨方法改善人骨髓间充质干细胞黏附的研究进展。在简要概述细胞黏附过程和细胞外基质蛋白的基础上，综述了间充质干细胞和成骨细胞与生物材料的黏附以及这种黏附对其向成骨细胞分化的影响。
Cell adhesion to scaffolds has remained one of the challenges in tissue engineering. Although protein surface modification has been proven to enhance cell adhesion and retention, its specificity depending on cell and biomaterial types means that the best protein and concentration must be established for each specific application. This review focuses on the improvement of cell adhesion for human mesenchymal stem cells with an osteogenesis approach. A brief outline of the cell adhesion process and extracellular matrix proteins precedes an overview of works focused on the adhesion of mesenchymal stem cells and osteoblasts to biomaterials and this effect in their differentiation into osteoblasts.