The Cardiac Pacemaker and Conduction System Develops From Embryonic Myocardium that Retains Its Primitive Phenotype
The Cardiac Pacemaker and Conduction System Develops From Embryonic Myocardium that Retains Its Primitive Phenotype
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DOI：
10.1097/fjc.0b013e3181e775d3
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发表时间：
2010-07-01
影响因子：
3
通讯作者：
Moorman, Antoon F. M.
中科院分区：
文献类型：
--
作者：
Bakker, Martijn L.;Christoffels, Vincent M.;Moorman, Antoon F. M.
心脏传导系统的疾病经常发生，可能会导致危及生命的心律失常，需要药物治疗或植入电子起搏器。由于起搏器心肌的分子调控知识有限，目前尚不可能修复或再生传导系统组件。心脏传导系统的起源和发展几十年来一直是争论的主题。这篇综述将讨论我们对传导系统发育的分子调控的最新进展。我们认为，心脏传导系统的成分来源于胚胎心肌，胚胎心肌保持了其原始表型的基本特征，而邻近心肌分化为工作心肌。
Disorders of the cardiac conduction system occur frequently and may cause life-threatening arrhythmias requiring medication or electronic pacemaker implantation. Repair or regeneration of conduction system components is currently not possible due to limited knowledge of the molecular regulation of pacemaker myocardium. Origin and development of the cardiac conduction system have been subject to debate for many decades. This review will discuss recent advances in our understanding of the molecular regulation of the development of the conduction system. We conclude that the components of the cardiac conduction system originate from embryonic myocardium that has maintained essential features of its primitive phenotype, whereas the adjacent myocardium differentiates into working myocardium.