Update on the genetics of the fibromyalgia syndrome
Update on the genetics of the fibromyalgia syndrome
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DOI：
10.1016/j.berh.2015.04.018
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发表时间：
2015-02-01
影响因子：
5.2
通讯作者：
Buskila, Dan
中科院分区：
文献类型：
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作者：
Ablin, Jacob N.;Buskila, Dan
纤维肌痛综合征(FMS)是一种以慢性广泛性疼痛和压痛为特征的疾病，是一种复杂的疾病，被认为代表了集中性疼痛的范例。FMS表现出明显的家族聚集性，因此被认为具有遗传背景。在这一领域已经进行了多个候选基因研究，重点是在疼痛传递和处理中发挥作用的靶基因。虽然过去许多研究都集中在与神经递质系统相关的标记物，如儿茶酚胺(COMT)和5-羟色胺，但最近出现了新的靶基因。此外，全基因组测序扫描(基因组全关联研究)正越来越多地被用于包括FMS在内的慢性疼痛的研究。Micro RNAs是与转录后抑制基因表达相关的另一个新的研究领域，目前正在研究FMS的发病机制。(C)2015爱思唯尔有限公司。保留所有权利。
Fibromyalgia syndrome (FMS), a condition characterized by chronic widespread pain and tenderness, is a complex condition considered to represent a paradigm of centralized pain. FMS has demonstrated a clear familial aggregation, and hence it is considered to have a genetic background. Multiple candidate-gene studies have been conducted in this field, focusing on target genes that play a role in the transmission and processing of pain. While many of these have focused in the past on markers related to neurotransmitter systems such as catecholamines (catechol-O-methyltransferase (COMT)) and serotonin, novel target genes have recently emerged. In addition, genome-wide sequencing scanning (genome-wide association study (GWAS)) is increasingly being harnessed for the study of chronic pain, including FMS. Micro RNAs are another novel field of research related to posttranscriptional inhibition of gene expression, which are currently regarding the pathogenesis of FMS. (C) 2015 Elsevier Ltd. All rights reserved.