Measurement of 129Xe gas apparent diffusion coefficient anisotropy in an elastase-instilled rat model of emphysema
Measurement of 129Xe gas apparent diffusion coefficient anisotropy in an elastase-instilled rat model of emphysema
复制标题
DOI：
10.1002/mrm.24224
复制
发表时间：
2013-01-01
影响因子：
3.3
通讯作者：
Santyr, Giles E.
中科院分区：
文献类型：
--
作者：
Boudreau, Mathieu;Xu, Xiaojun;Santyr, Giles E.
超极化惰性气体（3He和129Xe）表观扩散系数（ADC）测量显示出对肺微结构（即肺泡）变化，特别是肺气肿的显著敏感性。超极化惰性气体的ADC强烈依赖于扩散时间（?），而3He ADC在？从几毫秒到几百微秒不等。在本研究中，129Xe扩散的各向异性及其对？在出芽圆柱模型和弹性酶灌注大鼠肺气肿模型中进行了数值研究。测量全肺纵向ADC （DL）和横向ADC （DT）。= 6、50和100 ms在73.5 mT，并与从肺组织学获得的平均线性截距（Lm）的测量结果相关。DT显著增加（P = 0.0021）。假手术组（0.0021 +/- 0.0005 cm2/s）和注射弹性酶组（0.005 +/- 0.001 cm2/s）之间的差异= 6 ms, DT (？= 6 ms)和Lm， Pearson相关系数为0.90。本研究证实，129Xe DT升高与大鼠弹性蛋白酶注入引起的肺泡间隙增大有关。《理性医学杂志》，2013。(c) 2012 Wiley期刊有限公司
Hyperpolarized noble gas (3He and 129Xe) apparent diffusion coefficient (ADC) measurements have shown remarkable sensitivity to microstructural (i.e., alveolar) changes in the lung, particularly emphysema. The ADC of hyperpolarized noble gases depends strongly on the diffusion time (?), and 3He ADC has been shown to be anisotropic for ? ranging from a few milliseconds down to a few hundred microseconds. In this study, the anisotropic nature of 129Xe diffusion and its dependence on ? were investigated both numerically, in a budded cylinder model, and in vivo, in an elastase-instilled rat model of emphysema. Whole lung longitudinal ADC (DL) and transverse ADC (DT) were measured for ? = 6, 50, and 100 ms at 73.5 mT, and correlated with measurements of the mean linear intercept (Lm) obtained from lung histology. A significant increase (P = 0.0021) in DT was measured for ? = 6 ms between the sham (0.0021 +/- 0.0005 cm2/s) and elastase-instilled (0.005 +/- 0.001 cm2/s) cohorts, and a strong correlation was measured between DT (? = 6 ms) and Lm, with a Pearson's correlation coefficient of 0.90. This study confirms that 129Xe DT increases correlate with alveolar space enlargement due to elastase instillation in rats. Magn Reson Med, 2013. (c) 2012 Wiley Periodicals, Inc.