Tumor angiogenesis as a prognostic marker in operable non-small cell lung cancer
Tumor angiogenesis as a prognostic marker in operable non-small cell lung cancer
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DOI：
10.1016/s0003-4975(97)01416-1
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发表时间：
1998-05-01
影响因子：
4.6
通讯作者：
Tanigawa, N
中科院分区：
文献类型：
--
作者：
Matsuyama, K;Chiba, Y;Tanigawa, N
背景最近的证据表明，肿瘤血管生成与许多恶性肿瘤患者的预后相关。然而，很少有人知道的意义，肿瘤微血管密度的评估与抗CD 34抗体在肺癌患者。肿瘤组织获自101例可手术非小细胞肺癌患者。肿瘤相关微血管的免疫组织化学检测使用抗CD 34抗体直接针对内皮标志物。在x200视野下记录三个最多血管区域的平均计数。由于特异性和最小背景染色，CD 34染色易于判读。Kaplan-Meier方法显示微血管计数和总生存率之间存在统计学显著差异。微血管计数被确定为唯一显著和独立的预后标志物。在单因素和多因素分析中，微血管计数与血行转移的发生显著相关，但与淋巴结转移的发生无关。肿瘤血管是一个独立的预后因素，并对血行转移的发展很重要。(C)1998年，美国胸外科医师协会（Society of Thoracic Surgeons）
Background. Recent evidence suggests that tumor angiogenesis is associated with patient outcome in a number of malignancies. However, little is known about the significance of tumor microvessel density as evaluated by an anti-CD34 antibody in patients with lung cancer.Methods. Tumor tissues were obtained from 101 patients with operable non-small cell lung cancers. Immunohistochemical detection of tumor-associated microvessels was performed using anti-CD34 antibodies directed against endothelial markers. Average counts of the three most vascular areas on a x200 field were recorded.Results. Staining for CD34 was easy to interpret because of specific and minimal background staining. The Kaplan-Meier method showed a statistically significant difference between the microvessel count and overall survival. The microvessel count was identified as the only significant and independent prognostic marker. In both univariate and multivariate analyses, the microvessel count was significantly related to the development of hematogenous metastasis but failed to associate with the development of nodal metastasis.Conclusions. Tumor vascularity is an independent prognostic factor and important for the development of hematogenous metastasis. (C) 1998 by The Society of Thoracic Surgeons.