An Attempt to Transmit Poliomyelitis by the Bite of Lyperosia Irritans
An Attempt to Transmit Poliomyelitis by the Bite of Lyperosia Irritans
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试图通过红斑狼疮虫叮咬传播脊髓灰质炎
DOI：
10.1093/infdis/15.1.1
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发表时间：
1914
期刊：
影响因子：
--
通讯作者：
E. Francis
中科院分区：
文献类型：
--
作者：
E. Francis
在实验1中，从接种脊髓灰质炎病毒开始，直到猕猴死亡为止，在6天内每天允许刺红鼠叮咬一只恒河猴两次，在同一时间内每天允许叮咬一只新鲜的恒河猴两次，在随后的6天内每天允许叮咬两次。这只猴子一直很好。实验2中，从接种脊髓灰质炎病毒之日起至猕猴死亡，在4天内每天叮咬2只恒河猴，并在此期间以及随后的8天和7天内，每天叮咬2只新鲜的恒河猴（6和7）。猴子6保持健康。7号猴子在7天结束时意外死亡。它的一部分颈髓被接种到一只新鲜的猴子身上，这只猴子仍然健康。实验2中使用的苍蝇被允许从第一次接触受感染的猴子的第12天开始，每天叮咬一只新鲜的恒河猴3次，持续8天。猴子8保持健康。1913年10月27日，猴子2、3、6和8仍然健康。
Lyperosia irritans in Experiment 1 were allowed to bite a rhesus monkey twice daily for a period of six days from the time of inoculation with poliomyelitis virus until its death, and were allowed to bite a fresh rhesus monkey twice daily during the same period, and twice daily during the succeeding six days. This monkey remained well. Lyperosia irritans in Experiment 2 were allowed to bite a rhesus monkey twice daily for a period of four days from the time of inoculation with poliomyelitis virus until its death, and were allowed to bite two fresh rhesus monkeys (6 and 7) twice daily during the above period, and during the succeeding eight and seven days, respectively. Monkey 6 remained healthy. Monkey 7 was accidentally killed at the end of the seven-day period. A portion of its cervical cord was inoculated into a fresh monkey which remained healthy. The flies employed in Experiment 2 were allowed to bite a fresh rhesus monkey (8) three times daily for eight days beginning on the twelfth day from the first exposure of the flies to an infected monkey. Monkey 8 remained healthy. Monkeys 2, 3, 6 and 8 were still healthy October 27, 1913.