Injury-Induced Cellular Plasticity Drives Intestinal Regeneration.
Injury-Induced Cellular Plasticity Drives Intestinal Regeneration.
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DOI：
10.1016/j.jcmgh.2021.12.005
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发表时间：
2022
影响因子：
7.2
通讯作者：
Dempsey PJ
中科院分区：
文献类型：
--
作者：
Meyer AR;Brown ME;McGrath PS;Dempsey PJ
肠道的上皮衬里，特别是干细胞隔室，会受到腔内环境恶劣条件的影响，并且也容易受到辐射和化疗等遗传毒性物质的影响。因此，肠上皮细胞恢复到干细胞状态的能力是在粘膜损伤部位再生肠上皮的重要生理损伤反应。许多参与维持干细胞生态位的信号网络被激活作为损伤反应的一部分，以促进细胞可塑性和再生。每种细胞类型和信号通路的相对贡献是正在进行的研究的一个关键领域，可能取决于损伤的性质以及肠道内的区域特异性。本文就多细胞合作修复肠上皮损伤的研究进展作一综述。
The epithelial lining of the intestine, particularly the stem cell compartment, is affected by harsh conditions in the luminal environment and also is susceptible to genotoxic agents such as radiation and chemotherapy. Therefore, the ability for intestinal epithelial cells to revert to a stem cell state is an important physiological damage response to regenerate the intestinal epithelium at sites of mucosal injury. Many signaling networks involved in maintaining the stem cell niche are activated as part of the damage response to promote cellular plasticity and regeneration. The relative contribution of each cell type and signaling pathway is a critical area of ongoing research, likely dependent on the nature of injury as well as the regional specification within the intestine. Here, we review the current understanding of the multicellular cooperation to restore the intestinal epithelium after damage.
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64.8
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影响因子：
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作者：
Klostermeier UC;Barann M;Wittig M;Häsler R;Franke A;Gavrilova O;Kreck B;Sina C;Schilhabel MB;Schreiber S;Rosenstiel P
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