Premature menopause in a multi-ethnic population study of the menopause transition
Premature menopause in a multi-ethnic population study of the menopause transition
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DOI：
10.1093/humrep/deg005
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发表时间：
2003-01-01
影响因子：
6.1
通讯作者：
Santoro, N
中科院分区：
文献类型：
--
作者：
Luborsky, JL;Meyer, P;Santoro, N
背景技术背景：过早绝经，也称为卵巢早衰（POF），其特征是40岁之前月经停止。关于POF的一般患病率或按种族群体的患病率的信息很少。也缺乏关于POF与健康指标之间关系的信息。方法：在美国的7个地点对40-55岁的妇女进行了横断面调查，以确定围绝经期基于社区的多种族纵向研究（全国妇女研究，SWAN）的资格。访谈数据用于（i）确定总体和各种族自我报告的POF患病率，以及（ii）评估POF与选定的与健康相关的自我报告变量的关联。POF病例仅包括无明显POF原因的女性。结果：1.1%（126/11652）的女性报告了POF。按种族划分，1.0%（95%CI，0.7-1.4）的高加索人、1.4%（95%CI，1.0-2.1）的非裔美国人、1.4%（95%CI，0.8-2.5）的西班牙裔、0.5%（95%CI，0.1-1.9）的中国人和0.1%（95%CI，0.02-1.1）的日本女性患有POF。各种族组之间的频率差异具有统计学显著性（P = 0.01）。只有白人，非洲裔美国人和西班牙裔妇女被纳入进一步的分析，因为太少的亚洲妇女有POF。在多变量模型中，POF与骨质疏松症、女性激素使用（不包括口服避孕药）、较高的体重指数（BMI）和当前吸烟独立相关，调整教育水平、支付基本费用的能力、地点和年龄后。在白人女性中，使用女性激素、骨质疏松、严重残疾和吸烟与POF显著相关。相比之下，非裔美国妇女的POF与较高的BMI和女性激素使用有关，但与骨质疏松无关。结论：POF的患病率似乎因种族而异。与POF相关的健康因素也因种族而异，但由于横断面研究设计，不可能确定因果关系。POF的健康风险有待进一步研究。
BACKGROUND: Premature menopause, also termed premature ovarian failure (POF), is characterized by cessation of menstruation before the age of 40 years. Little information is available on the general prevalence of POF or on the prevalence by ethnic group. There is also a lack of information on the association of POF with health indicators. METHODS: A cross-sectional survey of women aged 40-55 years was conducted at seven sites in the USA to determine eligibility for a community-based, multi-ethnic longitudinal study of the peri-menopause (The Study of Women Across the Nation, SWAN). Interview data were used to (i) determine the prevalence of self-reported POF overall and by ethnic group, and (ii) assess the association of POF with selected self-reported variables related to health. Cases of POF included only women with no discernible cause for POF. RESULTS: POF was reported by 1.1% (126/11 652) of women. By ethnicity, 1.0% (95% CI, 0.7-1.4) of Caucasian, 1.4% (95% CI, 1.0-2.1) of African American, 1.4% (95% CI, 0.8-2.5) of Hispanic, 0.5% (95% CI, 0.1-1.9) of Chinese and 0.1% (95% CI, 0.02-1.1) of Japanese women experienced POF. The differences in frequency across ethnic groups were statistically significant (P = 0.01). Only Caucasian, African American and Hispanic women were included in further analyses since too few Asian women had POF. In a multivariate model, POF was independently associated with osteoporosis, female hormone use (excluding oral contraceptives), higher body mass index (BMI) and current smoking after adjustment for education level, ability to pay for basics, site and age at interview. In Caucasian women, use of female hormones, osteoporosis, severe disability and smoking were significantly associated with POF. In contrast, POF in African American women was associated with higher BMI and female hormone use, but not osteoporosis. CONCLUSIONS: The prevalence of POF appears to vary by ethnicity. Health factors associated with POF also vary by ethnicity but because of the cross-sectional study design, it is not possible to determine cause and effect relationships. Health risks of POF would benefit from further study.